{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:50:05Z","timestamp":1791924605497,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":80,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jlr.org"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1194\/jlr.ra120000888","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T22:45:14Z","timestamp":1594334714000},"page":"1271-1286","update-policy":"https:\/\/doi.org\/10.1194\/jlr.f110.005975","source":"Crossref","is-referenced-by-count":203,"title":["Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance"],"prefix":"10.1016","volume":"61","author":[{"given":"Rene C.","family":"Adam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivory J.","family":"Mintah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey A.","family":"Alexa-Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Shihanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poulabi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara C.","family":"Hamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye In","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen H.","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristopher","family":"Van Hout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Gromada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Yancopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Sleeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Gusarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.RA120000888_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrg2481","article-title":"Plasma lipoproteins: genetic influences and clinical implications","volume":"10","author":"Hegele","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1194\/jlr.RA120000888_bib2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/heartjnl-2018-314253","article-title":"Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease","volume":"105","author":"Akyea","year":"2019","journal-title":"Heart."},{"key":"10.1194\/jlr.RA120000888_bib3","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"2863","article-title":"Familial hypercholesterolemia","author":"Goldstein","year":"2001"},{"key":"10.1194\/jlr.RA120000888_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/MOL.0000000000000600","article-title":"New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk","volume":"30","author":"Kersten","year":"2019","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1194\/jlr.RA120000888_bib5","first-page":"70","article-title":"Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans","volume":"119","author":"Romeo","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.RA120000888_bib6","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1056\/NEJMoa1002926","article-title":"Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia","volume":"363","author":"Musunuru","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib7","doi-asserted-by":"crossref","first-page":"E1266","DOI":"10.1210\/jc.2012-1298","article-title":"Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization","volume":"97","author":"Minicocci","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1194\/jlr.RA120000888_bib8","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2017.02.030","article-title":"ANGPTL3 deficiency and protection against coronary artery disease","volume":"69","author":"Stitziel","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1194\/jlr.RA120000888_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1612790","article-title":"Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease","volume":"377","author":"Dewey","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1056\/NEJMoa1701329","article-title":"Cardiovascular and metabolic effects of ANGPTL3 antisense oligonucleotides","volume":"377","author":"Graham","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib11","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1194\/jlr.M054890","article-title":"ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys","volume":"56","author":"Gusarova","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib12","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1194\/jlr.M075689","article-title":"ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance","volume":"58","author":"Haller","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib13","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.molmet.2017.06.014","article-title":"ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase","volume":"6","author":"Chi","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1194\/jlr.RA120000888_bib14","doi-asserted-by":"crossref","first-page":"33742","DOI":"10.1074\/jbc.M203215200","article-title":"ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase","volume":"277","author":"Shimizugawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.RA120000888_bib15","doi-asserted-by":"crossref","first-page":"16109","DOI":"10.1073\/pnas.1315292110","article-title":"Mice lacking ANGPTL8 (betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.RA120000888_bib16","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1210\/en.2016-1894","article-title":"ANGPTL8 blockade with a monoclonal antibody promotes triglyceride clearance, energy expenditure and weight loss in mice","volume":"158","author":"Gusarova","year":"2017","journal-title":"Endocrinology."},{"key":"10.1194\/jlr.RA120000888_bib17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1161\/01.ATV.0000252827.51626.89","article-title":"Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase","volume":"27","author":"Shimamura","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.RA120000888_bib18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/7766","article-title":"A novel endothelial-derived lipase that modulates HDL metabolism","volume":"21","author":"Jaye","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.RA120000888_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1172\/JCI16306","article-title":"Endothelial lipase is a major determinant of HDL level","volume":"111","author":"Ishida","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.RA120000888_bib20","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1253\/circj.CJ-10-0934","article-title":"Update on the role of endothelial lipase in high-density lipoprotein metabolism, reverse cholesterol transport, and atherosclerosis","volume":"74","author":"Yasuda","year":"2010","journal-title":"Circ. J."},{"key":"10.1194\/jlr.RA120000888_bib21","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1161\/01.CIR.0000092889.24713.DC","article-title":"Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase","volume":"108","author":"Maugeais","year":"2003","journal-title":"Circulation."},{"key":"10.1194\/jlr.RA120000888_bib22","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1074\/jbc.M807683200","article-title":"Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase","volume":"284","author":"Nijstad","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.RA120000888_bib23","doi-asserted-by":"crossref","first-page":"13735","DOI":"10.1074\/jbc.M807899200","article-title":"Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL)","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.RA120000888_bib24","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1194\/jlr.M054882","article-title":"Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion","volume":"56","author":"Wang","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib25","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJMc1705994","article-title":"ANGPTL3 inhibition in homozygous familial hypercholesterolemia","volume":"377","author":"Gaudet","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib26","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nbt822","article-title":"High-throughput engineering of the mouse genome coupled with high-resolution expression analysis","volume":"21","author":"Valenzuela","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1194\/jlr.RA120000888_bib27","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1073\/pnas.89.10.4471","article-title":"Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells","volume":"89","author":"Piedrahita","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.RA120000888_bib28","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/CIRCULATIONAHA.118.039107","article-title":"Inhibition of angiopoietin-like protein 3 with a monoclonal antibody reduces triglycerides in hypertriglyceridemia","volume":"140","author":"Ahmad","year":"2019","journal-title":"Circulation."},{"key":"10.1194\/jlr.RA120000888_bib29","article-title":"Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank","author":"Van Hout","year":"2019","journal-title":"bioRxiv."},{"key":"10.1194\/jlr.RA120000888_bib30","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/ng.3190","article-title":"Efficient Bayesian mixed model analysis increases association power in large cohorts","volume":"47","author":"Loh","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1194\/jlr.RA120000888_bib31","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1073\/pnas.1323896111","article-title":"Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes","volume":"111","author":"Macdonald","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.RA120000888_bib32","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1073\/pnas.1324022111","article-title":"Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice","volume":"111","author":"Murphy","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.RA120000888_bib33","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1172\/JCI86610","article-title":"ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors","volume":"126","author":"Gordts","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.RA120000888_bib34","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1093\/nar\/gks273","article-title":"TricycloDNA-modified oligo-2\u2032-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues\u2013a comparative study of oligonucleotide length, design and chemistry","volume":"40","author":"Murray","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.RA120000888_bib35","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1021\/pr201223p","article-title":"Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression","volume":"11","author":"Barr","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1194\/jlr.RA120000888_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jprot.2015.01.019","article-title":"Enhancing metabolomics research through data mining","volume":"127","author":"Mart\u00ednez-Arranz","year":"2015","journal-title":"J. Proteomics."},{"key":"10.1194\/jlr.RA120000888_bib37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1194\/jlr.RA120000888_bib38","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1056\/NEJM197811302992207","article-title":"Plasma high-density lipoproteins","volume":"299","author":"Tall","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib39","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1172\/JCI5578","article-title":"Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels","volume":"103","author":"Jiang","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.RA120000888_bib40","doi-asserted-by":"crossref","first-page":"11630","DOI":"10.1073\/pnas.1515374112","article-title":"Hepatic ANGPTL3 regulates adipose tissue energy homeostasis","volume":"112","author":"Wang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.RA120000888_bib41","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1194\/jlr.M500366-JLR200","article-title":"Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-\/- and LDLR-\/- mice","volume":"46","author":"Ko","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib42","first-page":"1042","article-title":"Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans","volume":"119","author":"Edmondson","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.RA120000888_bib43","doi-asserted-by":"crossref","first-page":"12485","DOI":"10.1038\/s41598-017-12882-7","article-title":"Impact of endothelial lipase on cholesterol efflux capacity of serum and high-density lipoprotein","volume":"7","author":"Schilcher","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1194\/jlr.RA120000888_bib44","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1073\/pnas.86.15.5810","article-title":"Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins","volume":"86","author":"Kowal","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.RA120000888_bib45","doi-asserted-by":"crossref","first-page":"28767","DOI":"10.1074\/jbc.270.48.28767","article-title":"Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway","volume":"270","author":"Mortimer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.RA120000888_bib46","doi-asserted-by":"crossref","first-page":"178","DOI":"10.7555\/JBR.28.20140019","article-title":"Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion","volume":"28","author":"Fisher","year":"2014","journal-title":"J. Biomed. Res."},{"key":"10.1194\/jlr.RA120000888_bib47","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1194\/jlr.M800130-JLR200","article-title":"The hepatic uptake of VLDL in lrp-ldlr\u2212\/\u2212vldlr\u2212\/\u2212 mice is regulated by LPL activity and involves proteoglycans and SR-BI","volume":"49","author":"Hu","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib48","first-page":"3236","article-title":"Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice","volume":"119","author":"Stanford","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1194\/jlr.RA120000888_bib49","doi-asserted-by":"crossref","first-page":"34331","DOI":"10.1074\/jbc.M302181200","article-title":"Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway","volume":"278","author":"Fuki","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.RA120000888_bib50","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1194\/jlr.C500007-JLR200","article-title":"Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice","volume":"46","author":"Espirito Santo","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib51","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1161\/ATVBAHA.113.301637","article-title":"Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice","volume":"33","author":"Foley","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.RA120000888_bib52","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1021\/bi00171a017","article-title":"Identification of a lipolysis-stimulated receptor that is distinct from the LDL receptor and the LDL receptor-related protein","volume":"33","author":"Yen","year":"1994","journal-title":"Biochemistry."},{"key":"10.1194\/jlr.RA120000888_bib53","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1073\/pnas.0133792100","article-title":"Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion","volume":"100","author":"Fujino","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.RA120000888_bib54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrcardio.2015.208","article-title":"Dyslipidaemia in 2015: advances in treatment of dyslipidaemia","volume":"13","author":"Grundy","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1194\/jlr.RA120000888_bib55","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1161\/01.RES.0000130657.00222.39","article-title":"Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins","volume":"94","author":"Broedl","year":"2004","journal-title":"Circ. Res."},{"key":"10.1194\/jlr.RA120000888_bib56","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/ATVBAHA.118.312021","article-title":"Metabolomic signature of angiopoietin-like protein 3 deficiency in fasting and postprandial state","volume":"39","author":"Tikkanen","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.RA120000888_bib57","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0305-0491(82)90252-8","article-title":"Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species","volume":"71","author":"Ha","year":"1982","journal-title":"Comp. Biochem. Physiol. B."},{"key":"10.1194\/jlr.RA120000888_bib58","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0022-2275(20)36966-2","article-title":"Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins","volume":"34","author":"Greeve","year":"1993","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib59","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1194\/jlr.RA119000419","article-title":"Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice","volume":"61","author":"Pouwer","year":"2020","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJMoa1307095","article-title":"Loss-of-function mutations in APOC3, triglycerides, and coronary disease","volume":"371","author":"Crosby","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib61","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa1308027","article-title":"Loss-of-function mutations in APOC3 and risk of ischemic vascular disease","volume":"371","author":"J\u00f8rgensen","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib62","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1056\/NEJMoa1510926","article-title":"Inactivating variants in ANGPTL4 and risk of coronary artery disease","volume":"374","author":"Dewey","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1194\/jlr.RA120000888_bib63","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/ATVBAHA.118.311476","article-title":"Effects of APOC3 heterozygous deficiency on plasma lipid and lipoprotein metabolism","volume":"39","author":"Reyes-Soffer","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1194\/jlr.RA120000888_bib64","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0022-2275(20)30466-1","article-title":"Characterization of the lipolytic activity of endothelial lipase","volume":"43","author":"McCoy","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.RA120000888_bib65","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0005-2760(78)90216-3","article-title":"Comparison of the phospholipase activity of bovine milk lipoprotein lipase against rat plasma very low density and high density lipoprotein","volume":"531","author":"Eisenberg","year":"1978","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.RA120000888_bib66","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1016\/S0021-9258(19)40996-4","article-title":"Purification from human plasma of a heparin-released lipase with activity against triglyceride and phospholipids","volume":"250","author":"Ehnholm","year":"1975","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520436922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520436922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.RA120000888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:22:28Z","timestamp":1696368148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520436922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":66,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0022227520436922"],"URL":"https:\/\/doi.org\/10.1194\/jlr.ra120000888","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}