{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:20:54Z","timestamp":1793107254961,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1077703"],"award-info":[{"award-number":["APP1077703"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1124762"],"award-info":[{"award-number":["APP1124762"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1143224"],"award-info":[{"award-number":["APP1143224"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1047138"],"award-info":[{"award-number":["1047138"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jlr.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1194\/jlr.ra120001126","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T13:08:30Z","timestamp":1608728910000},"page":"100016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-321X","authenticated-orcid":false,"given":"Stacey N.","family":"Keenan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1441-1295","authenticated-orcid":false,"given":"William","family":"De Nardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-198X","authenticated-orcid":false,"given":"Jieqiong","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-1878","authenticated-orcid":false,"given":"Ralf B.","family":"Schittenhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2551-4174","authenticated-orcid":false,"given":"Magdalene K.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-6630","authenticated-orcid":false,"given":"James G.","family":"Granneman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-1152","authenticated-orcid":false,"given":"Elizabeth","family":"Hinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-4188","authenticated-orcid":false,"given":"Matthew J.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1194\/jlr.RA120001126_bib1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","article-title":"The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis","volume":"1862","author":"Sztalryd","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1194\/jlr.RA120001126_bib2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbalip.2009.04.002","article-title":"PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores","volume":"1791","author":"Bickel","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1194\/jlr.RA120001126_bib3","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1194\/jlr.R700014-JLR200","article-title":"Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis","volume":"48","author":"Brasaemle","year":"2007","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1194\/jlr.RA120001126_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev-nutr-071813-105410","article-title":"The Perilipins: major cytosolic lipid droplet-associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis","volume":"36","author":"Kimmel","year":"2016","journal-title":"Annu, Rev. Nutr."},{"key":"10.1194\/jlr.RA120001126_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.biochi.2013.08.026","article-title":"Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection","volume":"96","author":"Sztalryd","year":"2014","journal-title":"Biochimie"},{"key":"10.1194\/jlr.RA120001126_bib6","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.2337\/db06-0399","article-title":"OXPAT\/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization","volume":"55","author":"Wolins","year":"2006","journal-title":"Diabetes"},{"key":"10.1194\/jlr.RA120001126_bib7","doi-asserted-by":"crossref","first-page":"14232","DOI":"10.1074\/jbc.M601682200","article-title":"MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha","volume":"281","author":"Yamaguchi","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbalip.2006.11.011","article-title":"LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues","volume":"1771","author":"Dalen","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1194\/jlr.RA120001126_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103062","article-title":"Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise","volume":"9","author":"Mason","year":"2014","journal-title":"PLoS One"},{"key":"10.1194\/jlr.RA120001126_bib10","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12154","article-title":"Higher PLIN5 but not PLIN3 content in isolated skeletal muscle mitochondria following acute in\u00a0vivo contraction in rat hindlimb","volume":"2","author":"Ramos","year":"2014","journal-title":"Physiol. Rep"},{"key":"10.1194\/jlr.RA120001126_bib11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1113\/jphysiol.2012.240952","article-title":"Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5","volume":"591","author":"Shepherd","year":"2013","journal-title":"J.\u00a0Physiol."},{"key":"10.1194\/jlr.RA120001126_bib12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tem.2015.01.005","article-title":"Unraveling the roles of PLIN5: linking cell biology to physiology","volume":"26","author":"Mason","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1194\/jlr.RA120001126_bib13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.molmet.2014.06.002","article-title":"PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle","volume":"3","author":"Mason","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1194\/jlr.RA120001126_bib14","doi-asserted-by":"crossref","first-page":"23852","DOI":"10.1074\/jbc.M111.328708","article-title":"Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation","volume":"287","author":"Kuramoto","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep38310","article-title":"Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle","volume":"6","author":"Laurens","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1194\/jlr.RA120001126_bib16","doi-asserted-by":"crossref","first-page":"15707","DOI":"10.1074\/jbc.M110.207779","article-title":"Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein","volume":"286","author":"Wang","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib17","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1074\/jbc.M110.180711","article-title":"Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase","volume":"286","author":"Granneman","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib18","doi-asserted-by":"crossref","first-page":"R1094","DOI":"10.1152\/ajpregu.00130.2006","article-title":"Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise","volume":"291","author":"Talanian","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1194\/jlr.RA120001126_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/jbc.273.1.215","article-title":"Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in\u00a0vitro","volume":"273","author":"Anthonsen","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib20","doi-asserted-by":"crossref","first-page":"E500","DOI":"10.1152\/ajpendo.00361.2005","article-title":"Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue","volume":"290","author":"Watt","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1194\/jlr.RA120001126_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1194\/jlr.M055004","article-title":"CGI-58\/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization","volume":"56","author":"Sahu-Osen","year":"2015","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1194\/jlr.RA120001126_bib22","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1210\/en.2012-1127","article-title":"Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase","volume":"153","author":"Pagnon","year":"2012","journal-title":"Endocrinology"},{"key":"10.1194\/jlr.RA120001126_bib23","doi-asserted-by":"crossref","first-page":"34538","DOI":"10.1074\/jbc.M109.068478","article-title":"Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)","volume":"284","author":"Granneman","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib24","doi-asserted-by":"crossref","first-page":"15837","DOI":"10.1074\/jbc.M601097200","article-title":"Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms","volume":"281","author":"Miyoshi","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib25","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1074\/jbc.M605770200","article-title":"Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes","volume":"282","author":"Miyoshi","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib26","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1074\/jbc.M114.604744","article-title":"The interplay of protein kinase A and perilipin 5 regulates cardiac lipolysis","volume":"290","author":"Pollak","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib27","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.bbalip.2017.09.007","article-title":"Atorvastatin reduces lipid accumulation in the liver by activating protein kinase A-mediated phosphorylation of perilipin 5","volume":"1862","author":"Gao","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1194\/jlr.RA120001126_bib28","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.molcel.2019.12.003","article-title":"Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1","volume":"77","author":"Najt","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1194\/jlr.RA120001126_bib29","doi-asserted-by":"crossref","first-page":"12723","DOI":"10.1038\/ncomms12723","article-title":"Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1alpha\/SIRT1-dependent transcriptional regulation of mitochondrial function","volume":"7","author":"Gallardo-Montejano","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1194\/jlr.RA120001126_bib30","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.bbalip.2018.08.016","article-title":"Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2","volume":"1863","author":"Gemmink","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1194\/jlr.RA120001126_bib31","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1038\/s41598-019-41329-4","article-title":"Adipocyte lipolysis affects Perilipin 5 and cristae organization at the cardiac lipid droplet-mitochondrial interface","volume":"9","author":"Varghese","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1194\/jlr.RA120001126_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biocel.2017.07.021","article-title":"Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts","volume":"91","author":"Andersson","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1194\/jlr.RA120001126_bib33","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1074\/jbc.M808251200","article-title":"Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation","volume":"284","author":"Granneman","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bpj.2008.09.051","article-title":"Detecting protein complexes in living cells from laser scanning confocal image sequences by the cross correlation raster image spectroscopy method","volume":"96","author":"Digman","year":"2009","journal-title":"Biophys. J."},{"key":"10.1194\/jlr.RA120001126_bib35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jemt.21054","article-title":"Biosensor Forster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy","volume":"75","author":"Hinde","year":"2012","journal-title":"Microsc. Res. Tech."},{"key":"10.1194\/jlr.RA120001126_bib36","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2337\/db18-0670","article-title":"Perilipin 5 deletion in hepatocytes remodels lipid metabolism and causes hepatic insulin resistance in mice","volume":"68","author":"Keenan","year":"2019","journal-title":"Diabetes"},{"key":"10.1194\/jlr.RA120001126_bib37","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2337\/db17-0923","article-title":"Perilipin 5 deletion unmasks an endoplasmic reticulum stress-fibroblast growth factor 21 axis in skeletal muscle","volume":"67","author":"Montgomery","year":"2018","journal-title":"Diabetes"},{"key":"10.1194\/jlr.RA120001126_bib38","doi-asserted-by":"crossref","first-page":"42062","DOI":"10.1074\/jbc.M407462200","article-title":"Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes","volume":"279","author":"Subramanian","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib39","doi-asserted-by":"crossref","first-page":"30490","DOI":"10.1074\/jbc.M403920200","article-title":"CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome","volume":"279","author":"Yamaguchi","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib40","doi-asserted-by":"crossref","first-page":"18769","DOI":"10.1016\/S0021-9258(17)30578-1","article-title":"Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation","volume":"265","author":"Egan","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tem.2007.10.006","article-title":"Location, location: protein trafficking and lipolysis in adipocytes","volume":"19","author":"Granneman","year":"2008","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1194\/jlr.RA120001126_bib42","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1074\/jbc.M610580200","article-title":"Analysis of lipolytic protein trafficking and interactions in adipocytes","volume":"282","author":"Granneman","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib43","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1083\/jcb.200210169","article-title":"Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation","volume":"161","author":"Sztalryd","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1194\/jlr.RA120001126_bib44","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.1074\/jbc.M108329200","article-title":"Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system","volume":"277","author":"Souza","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib45","doi-asserted-by":"crossref","first-page":"51535","DOI":"10.1074\/jbc.M309591200","article-title":"Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis","volume":"278","author":"Zhang","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4161\/adip.20035","article-title":"Distinct roles for alpha-beta hydrolase domain 5 (ABHD5\/CGI-58) and adipose triglyceride lipase (ATGL\/PNPLA2) in lipid metabolism and signaling","volume":"1","author":"Lord","year":"2012","journal-title":"Adipocyte"},{"key":"10.1194\/jlr.RA120001126_bib47","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.celrep.2016.06.049","article-title":"Regulation of hepatic triacylglycerol metabolism by CGI-58 does not require ATGL co-activation","volume":"16","author":"Lord","year":"2016","journal-title":"Cell Rep."},{"key":"10.1194\/jlr.RA120001126_bib48","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1074\/jbc.M109.081877","article-title":"Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)","volume":"285","author":"Radner","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1194\/jlr.RA120001126_bib49","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.117.243253","article-title":"Novel pharmacological probes reveal ABHD5 as a locus of lipolysis control in white and brown adipocytes","volume":"363","author":"Rondini","year":"2017","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1194\/jlr.RA120001126_bib50","doi-asserted-by":"crossref","first-page":"E960","DOI":"10.1152\/ajpendo.00598.2014","article-title":"ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle","volume":"308","author":"Meex","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1194\/jlr.RA120001126_bib51","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bbalip.2011.10.017","article-title":"Distinct cellular pools of perilipin 5 point to roles in lipid trafficking","volume":"1821","author":"Bartholomew","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1194\/jlr.RA120001126_bib52","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1194\/jlr.M017939","article-title":"Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria","volume":"52","author":"Wang","year":"2011","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1194\/jlr.RA120001126_bib53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11892-020-01300-4","article-title":"Inter-organelle communication in the pathogenesis of mitochondrial dysfunction and insulin resistance","volume":"20","author":"Keenan","year":"2020","journal-title":"Curr. Diab. Rep."},{"key":"10.1194\/jlr.RA120001126_bib54","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hep.24338","article-title":"Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis","volume":"54","author":"Wu","year":"2011","journal-title":"Hepatology"},{"key":"10.1194\/jlr.RA120001126_bib55","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00125-010-1895-5","article-title":"Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice","volume":"54","author":"Turpin","year":"2011","journal-title":"Diabetologia"},{"key":"10.1194\/jlr.RA120001126_bib56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"key":"10.1194\/jlr.RA120001126_bib57","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/S0140-6736(10)60408-4","article-title":"Lipid-induced insulin resistance: unravelling the mechanism","volume":"375","author":"Samuel","year":"2010","journal-title":"Lancet"},{"key":"10.1194\/jlr.RA120001126_bib58","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ\u2014linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1194\/jlr.RA120001126_bib59","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1194\/jlr.RA120001126_bib60","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.RA120001126_bib61","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-1-59745-448-3_10","article-title":"The measurement of GLUT4 translocation in 3T3-L1 adipocytes","volume":"560","author":"Konstantopoulos","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1194\/jlr.RA120001126_bib62","doi-asserted-by":"crossref","first-page":"E128","DOI":"10.1152\/ajpendo.00084.2016","article-title":"Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training","volume":"311","author":"Mohktar","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1194\/jlr.RA120001126_bib63","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1016\/j.celrep.2016.08.005","article-title":"Disruption of the class IIa HDAC corepressor complex increases energy expenditure and lipid oxidation","volume":"16","author":"Gaur","year":"2016","journal-title":"Cell Rep."},{"key":"10.1194\/jlr.RA120001126_bib64","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1038\/s41596-018-0026-5","article-title":"Fit-free analysis of fluorescence lifetime imaging data using the phasor approach","volume":"13","author":"Ranjit","year":"2018","journal-title":"Nat. Protoc."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520437204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520437204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.RA120001126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:10:10Z","timestamp":1777417810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520437204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":64,"alternative-id":["S0022227520437204"],"URL":"https:\/\/doi.org\/10.1194\/jlr.ra120001126","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control","name":"articletitle","label":"Article Title"},{"value":"Journal of Lipid Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1194\/jlr.RA120001126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100016"}}