{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:32:55Z","timestamp":1770910375175,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":2961,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Lipid Research"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1194\/jlr.m027680","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T05:43:47Z","timestamp":1339566227000},"page":"1910-1919","source":"Crossref","is-referenced-by-count":11,"title":["Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1\/2-Sp3-dependent pathway"],"prefix":"10.1016","volume":"53","author":[{"given":"Maria Jo\u00e3o","family":"Nunes","sequence":"first","affiliation":[]},{"given":"Miguel","family":"Moutinho","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Milagre","sequence":"additional","affiliation":[]},{"given":"Maria Jo\u00e3o","family":"Gama","sequence":"additional","affiliation":[]},{"given":"Elsa","family":"Rodrigues","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1194\/jlr.M027680_bib1","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1073\/pnas.96.13.7238","article-title":"cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain","volume":"96","author":"Lund","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M027680_bib2","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/S0022-2275(20)32188-X","article-title":"Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation","volume":"39","author":"Bjorkhem","year":"1998","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M027680_bib3","doi-asserted-by":"crossref","first-page":"22980","DOI":"10.1074\/jbc.M303415200","article-title":"Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover","volume":"278","author":"Lund","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M027680_bib4","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1073\/pnas.0600316103","article-title":"Brain cholesterol turnover required for geranylgeraniol production and learning in mice","volume":"103","author":"Kotti","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M027680_bib5","doi-asserted-by":"crossref","first-page":"11394","DOI":"10.1073\/pnas.0805556105","article-title":"Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation","volume":"105","author":"Kotti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1194\/jlr.M027680_bib6","doi-asserted-by":"crossref","first-page":"34674","DOI":"10.1074\/jbc.M402324200","article-title":"Differential expression of cholesterol hydroxylases in Alzheimer's disease","volume":"279","author":"Brown","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M027680_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-4-1","article-title":"Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells","volume":"4","author":"Prasanthi","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1194\/jlr.M027680_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/mt.2009.175","article-title":"Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease","volume":"18","author":"Hudry","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1194\/jlr.M027680_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bbrc.2008.11.103","article-title":"Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors","volume":"378","author":"Shafaati","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.M027680_bib11","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1471-4159.2010.06612.x","article-title":"Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription","volume":"113","author":"Nunes","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.M027680_bib12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1471-4159.2008.05442.x","article-title":"Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors","volume":"106","author":"Milagre","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.M027680_bib13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1471-4159.2011.07577.x","article-title":"Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter","volume":"120","author":"Milagre","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.M027680_bib14","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3233\/JAD-2010-100651","article-title":"Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination","volume":"22","author":"Milagre","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1194\/jlr.M027680_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/138920208785133244","article-title":"Post-translational control of sp-family transcription factors","volume":"9","author":"Waby","year":"2008","journal-title":"Curr. Genomics."},{"key":"10.1194\/jlr.M027680_bib16","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1128\/MCB.19.5.3474","article-title":"Cooperation between phosphorylation and acetylation processes in transcriptional control","volume":"19","author":"Espinos","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.M027680_bib19","doi-asserted-by":"crossref","first-page":"38879","DOI":"10.1074\/jbc.M505733200","article-title":"Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M027680_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0960-0760(03)00230-9","article-title":"Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes","volume":"85","author":"Zhang","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1194\/jlr.M027680_bib21","doi-asserted-by":"crossref","first-page":"35775","DOI":"10.1074\/jbc.M305961200","article-title":"Acetylated sp3 is a transcriptional activator","volume":"278","author":"Ammanamanchi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M027680_bib22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neuint.2011.12.003","article-title":"Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells","volume":"60","author":"Milagre","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1194\/jlr.M027680_bib23","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","article-title":"Rapid detection of octamer binding proteins with 'mini-extracts\u2019, prepared from a small number of cells","volume":"17","author":"Schreiber","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.M027680_bib24","doi-asserted-by":"crossref","first-page":"12602","DOI":"10.1074\/jbc.M411709200","article-title":"Role of protein phosphatase 2A in mGluR5-regulated MEK\/ERK phosphorylation in neurons","volume":"280","author":"Mao","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M027680_bib25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1523\/JNEUROSCI.4109-07.2008","article-title":"Protein phosphatase 1-dependent bidirectional synaptic plasticity controls ischemic recovery in the adult brain","volume":"28","author":"Hedou","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1194\/jlr.M027680_bib26","doi-asserted-by":"crossref","first-page":"8382","DOI":"10.1128\/MCB.20.22.8382-8389.2000","article-title":"ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain","volume":"20","author":"Kasler","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.M027680_bib27","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1046\/j.1471-4159.1995.65020732.x","article-title":"Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain","volume":"65","author":"Gong","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.M027680_bib28","doi-asserted-by":"crossref","unstructured":"Qian, W., Yin, X., Hu, W., Shi, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., Gong, C. X., Liu, F., . 2100. Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease. J. Alzheimers Dis., 23: 617\u2013627.","DOI":"10.3233\/JAD-2010-100987"},{"key":"10.1194\/jlr.M027680_bib29","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/jnen\/59.10.880","article-title":"Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease","volume":"59","author":"Zhu","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1194\/jlr.M027680_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0169-328X(02)00488-6","article-title":"Up-regulation of mitogen-activated protein kinases ERK1\/2 and MEK1\/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease","volume":"109","author":"Pei","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1194\/jlr.M027680_bib32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0022-2275(20)32052-6","article-title":"Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients","volume":"41","author":"Lutjohann","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1194\/jlr.M027680_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2377-11-121","article-title":"Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study","volume":"11","author":"Zuliani","year":"2011","journal-title":"BMC Neurol."},{"key":"10.1194\/jlr.M027680_bib35","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/jcp.21104","article-title":"Sp3-mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk)","volume":"213","author":"Pages","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1194\/jlr.M027680_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/JME-10-0145","article-title":"Transcription of platelet-derived growth factor receptor alpha in Leydig cells involves specificity protein 1 and 3","volume":"46","author":"Bergeron","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"10.1194\/jlr.M027680_bib37","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s11033-008-9272-x","article-title":"ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells","volume":"36","author":"Petrovic","year":"2009","journal-title":"Mol. Biol. Rep."},{"key":"10.1194\/jlr.M027680_bib39","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.yjmcc.2007.12.008","article-title":"Fibroblast growth factor receptor 1 gene expression is required for cardiomyocyte proliferation and is repressed by Sp3","volume":"44","author":"Seyed","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1194\/jlr.M027680_bib40","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1074\/jbc.M300162200","article-title":"Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42\/44MAPK and transcription factor Sp3","volume":"278","author":"Bakovic","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M027680_bib41","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1093\/nar\/29.24.4994","article-title":"Transcription factor Sp3 is regulated by acetylation","volume":"29","author":"Braun","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.M027680_bib42","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1093\/emboj\/cdf510","article-title":"Transcription factor Sp3 is silenced through SUMO modification by PIAS1","volume":"21","author":"Sapetschnig","year":"2002","journal-title":"EMBO J."},{"key":"10.1194\/jlr.M027680_bib44","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/embor.2008.127","article-title":"SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing","volume":"9","author":"Stielow","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1194\/jlr.M027680_bib45","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood.V95.7.2391","article-title":"Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways","volume":"95","author":"Witt","year":"2000","journal-title":"Blood."},{"key":"10.1194\/jlr.M027680_bib46","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1006\/bbrc.1998.9041","article-title":"Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation","volume":"248","author":"Rivero","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.M027680_bib47","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0006-291X(03)00497-2","article-title":"Expression of alpha-ENaC2 is dependent on an upstream Sp1 binding motif and is modulated by protein phosphatase 1 in lung epithelial cells","volume":"303","author":"Chu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.M027680_bib48","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4161\/cc.7.5.5402","article-title":"Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation","volume":"7","author":"Spengler","year":"2008","journal-title":"Cell Cycle."},{"key":"10.1194\/jlr.M027680_bib49","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.bbamcr.2006.11.011","article-title":"Regulation of gene transcription by mitogen-activated protein kinase signaling pathways","volume":"1773","author":"Whitmarsh","year":"2007","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1194\/jlr.M027680_bib50","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1074\/jbc.M410775200","article-title":"Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease","volume":"280","author":"Liu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1194\/jlr.M027680_bib51","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pathophys.2009.02.008","article-title":"Protein phosphatase 2A in Alzheimer's disease","volume":"16","author":"Liu","year":"2009","journal-title":"Pathophysiology."},{"key":"10.1194\/jlr.M027680_bib52","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1097\/00001756-200006260-00030","article-title":"Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease","volume":"11","author":"Papassotiropoulos","year":"2000","journal-title":"Neuroreport."},{"key":"10.1194\/jlr.M027680_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbrc.2007.05.033","article-title":"Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway","volume":"359","author":"Famer","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1194\/jlr.M027680_bib17","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1093\/nar\/gkg262","article-title":"Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site","volume":"31","author":"Camarero","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1194\/jlr.M027680_bib18","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1128\/MCB.00560-06","article-title":"Phosphatidylinositol 3-kinase\/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene","volume":"26","author":"Zhang","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.M027680_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1471-4159.2001.00046.x","article-title":"Activation and redistribution of c-jun N-terminal kinase\/stress activated protein kinase in degenerating neurons in Alzheimer's disease","volume":"76","author":"Zhu","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1194\/jlr.M027680_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0022-3956(01)00050-4","article-title":"24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia","volume":"36","author":"Papassotiropoulos","year":"2002","journal-title":"J. Psychiatr. Res."},{"key":"10.1194\/jlr.M027680_bib38","doi-asserted-by":"crossref","first-page":"10777","DOI":"10.1128\/MCB.24.24.10777-10791.2004","article-title":"Sp3 proteins negatively regulate beta myosin heavy chain gene expression during skeletal muscle inactivity","volume":"24","author":"Tsika","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1194\/jlr.M027680_bib43","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1097-2765(02)00682-2","article-title":"SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization","volume":"10","author":"Ross","year":"2002","journal-title":"Mol. Cell."}],"container-title":["Journal of Lipid Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520418334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022227520418334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1194\/jlr.M027680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T22:48:21Z","timestamp":1637448501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022227520418334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0022227520418334"],"URL":"https:\/\/doi.org\/10.1194\/jlr.m027680","relation":{},"ISSN":["0022-2275"],"issn-type":[{"value":"0022-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}