{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:13:45Z","timestamp":1772579625637,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>Most pheochromocytomas\/paragangliomas should be evaluated with anatomical imaging (computed tomography or magnetic resonance imaging) followed by functional imaging (nuclear medicine modalities). Functional imaging assures that the tumor is indeed a pheochromocytoma\/paraganglioma and enables more thorough localization, especially detecting as many lesions as possible (in particular for metastatic disease). Functional imaging for pheochromocytomas\/paragangliomas, can use radiolabled ligands specific for pathways of synthesis, metabolism, and inactivation of catecholamines or nonspecific ligands. In an overview of the available nuclear medicine modalities, we summarize the accumulated experience and recommend when functional imaging should be applied to patients with pheochromocytoma\/paraganglioma.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1353.041","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:28:06Z","timestamp":1163464086000},"page":"374-382","source":"Crossref","is-referenced-by-count":42,"title":["Current Trends in Functional Imaging of Pheochromocytomas and Paragangliomas"],"prefix":"10.1111","volume":"1073","author":[{"given":"BARRY L.","family":"SHULKIN","sequence":"first","affiliation":[]},{"given":"IOANNIS","family":"ILIAS","sequence":"additional","affiliation":[]},{"given":"JAMES C.","family":"SISSON","sequence":"additional","affiliation":[]},{"given":"KAREL","family":"PACAK","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,9,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020152"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1212001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-4-267"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345810"},{"key":"e_1_2_6_6_2","first-page":"550","volume-title":"Functional Endocrine Pathology","author":"Tischler A.","year":"1998"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199906000-00001"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000074656"},{"key":"e_1_2_6_9_2","first-page":"349","article-title":"Radiolabeled adrenergic neuron\u2010blocking agents: adrenomedullary imaging with [131I]iodobenzylguanidine","volume":"21","author":"Wieland D.M.","year":"1980","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107023050103"},{"key":"e_1_2_6_11_2","first-page":"1138","article-title":"123I\u20104\u2010Amino\u20103\u2010iodobenzylguanidine (123I\u2010AIBG), a new sympatho\u2010adrenal imaging agent: comparison with 123I\u2010meta\u2010iodobenzylguanidine (123I\u2010MIBG)","volume":"27","author":"Shulkin B.","year":"1986","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_12_2","first-page":"1125","article-title":"PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma","volume":"33","author":"Shulkin B.L.","year":"1992","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2302021678"},{"key":"e_1_2_6_14_2","first-page":"22P","article-title":"PET epinephrine studies of pheochromocytoma","volume":"36","author":"Shulkin B.L.","year":"1995","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030235"},{"key":"e_1_2_6_16_2","first-page":"452","volume-title":"86th Annual Meeting of the American Endocrine Society","author":"Ilias I.","year":"2004"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2222010622"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.1.r99jl3035"},{"key":"e_1_2_6_19_2","first-page":"1324","article-title":"Discordant localization of [18\u2010F]\u2010fluorodeoxyglucose, in [18\u2010F]\u2010fluorodopamine\u2010negative metastatic pheochromocytoma sites","volume":"46","author":"Mamede M.","year":"2005","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000170060.52675.14"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.775"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.74.5.1082"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030262"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.2.685"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0939-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011013231805"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00181765"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70048-9"},{"key":"e_1_2_6_29_2","first-page":"1767","article-title":"Clinical impact of somatostatin receptor scintigraphy in the management of paragangliomas of the head and neck","volume":"44","author":"Duet M.","year":"2003","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200403000-00010"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2002.tb01667.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1254-6"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590100639"},{"key":"e_1_2_6_34_2","first-page":"213","article-title":"64Cu\u2010TETA\u2010octreotide as a PET imaging agent for patients with neuroendocrine tumors","volume":"42","author":"Anderson C.J.","year":"2001","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-1012-1"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0359"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-1632(03)00038-6"},{"key":"e_1_2_6_38_2","first-page":"708","article-title":"An intrapatient comparison of 99mTc\u2010EDDA\/HYNIC\u2010TOC with 111In\u2010DTPA\u2010octreotide for diagnosis of somatostatin receptor\u2010expressing tumors","volume":"44","author":"Gabriel M.","year":"2003","journal-title":"J. Nucl. Med."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1353.041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1353.041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T19:32:42Z","timestamp":1695670362000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1353.041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1196\/annals.1353.041"],"URL":"https:\/\/doi.org\/10.1196\/annals.1353.041","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}