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They may contribute to the associated autonomic changes. Through a central action, they may also be the effector mechanism in those with Morvan's syndrome and in some patients with limbic encephalitis. Evidence supporting this hypothesis includes the increased association of APNH with autoimmune diseases (in particular, myasthenia gravis and thymoma), the response to plasmapheresis, passive transfer of APNH to experimental animals by patients' plasma or immunoglobulins, the action of their serum on VGKC currents studied <jats:italic>in vitro<\/jats:italic>, and the presence in many patients of IgG antibodies to VGKCs.<\/jats:p>","DOI":"10.1196\/annals.1254.022","type":"journal-article","created":{"date-parts":[[2004,1,15]],"date-time":"2004-01-15T01:04:15Z","timestamp":1074128655000},"page":"202-210","source":"Crossref","is-referenced-by-count":98,"title":["Autoimmune Disorders of Neuronal Potassium Channels"],"prefix":"10.1111","volume":"998","author":[{"given":"JOHN","family":"NEWSOM\u2010DAVIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CAMILLA","family":"BUCKLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LINDA","family":"CLOVER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IAN","family":"HART","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL","family":"MADDISON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERDEM","family":"T\u00dcZ\u00dcM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANGELA","family":"VINCENT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb45499.x"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.180.4088.871"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179220"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1054"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91917-6"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90474-8"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.4.480"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014943"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7636"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.1.85"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322203"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8328"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.817"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017381"},{"key":"e_1_2_11_16_2","first-page":"88","article-title":"Myokymia and the benign fasciculation of muscular cramps","volume":"61","author":"Denny\u2010Brown D.","year":"1948","journal-title":"Trans. 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