{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:49:36Z","timestamp":1761580176534},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T00:00:00Z","timestamp":1138060800000},"content-version":"vor","delay-in-days":876,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> We have developed and validated an assay to detect serum antibodies specific for the ganglionic AChR. The assay uses ganglionic AChR solubilized from membranes of the human neuroblastoma cell line (IMR\u201032) as antigen. The ganglionic AChR is radiolabeled by complexing with <jats:sup>125<\/jats:sup>I\u2010epibatidine. Among patients with acquired dysautonomia, seropositivity is highly associated with the diagnosis of idiopathic or paraneoplastic autonomic neuropathy and can distinguish these disorders from other forms of autonomic dysfunction. Ganglionic AChR binding antibodies are detectable in 50% of patients with subacute autoimmune autonomic neuropathy (AAN). These patients often have a high antibody value (&gt;0.2 nmol\/L). Lower values (0.05\u20130.20 nmol\/L) are found in \u223c10% of patients with limited AAN.<\/jats:p>","DOI":"10.1196\/annals.1254.023","type":"journal-article","created":{"date-parts":[[2004,1,15]],"date-time":"2004-01-15T01:04:15Z","timestamp":1074128655000},"page":"211-214","source":"Crossref","is-referenced-by-count":17,"title":["Neuronal Ganglionic Acetylcholine Receptor Autoimmunity"],"prefix":"10.1111","volume":"998","author":[{"given":"STEVEN","family":"VERNINO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VANDA A.","family":"LENNON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302507"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5746"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/98.4.613"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.9.1675"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10556"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009213431204"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(01)00239-9"},{"key":"e_1_2_3_9_2","unstructured":"Low P.A. & J.G. McLeod. 1997. The autonomic neuropathies.InClinical Autonomic Disorders pp. 397\u2013401. Little Brown. Boston."},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.4065\/72.4.333"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1764"},{"key":"e_1_2_3_12_2","unstructured":"Vernino S. T. Kryzer & V. Lennon. 2002. Autoantibodies in autoimmune autonomic neuropathies and neuromuscular hyperexcitability disorders.InManual of Clinical Laboratory Immunology pp. 1013\u20131017. ASM Press. Washington D.C."},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10266"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11824-G"},{"key":"e_1_2_3_15_2","first-page":"390","article-title":"Regulation of acetylcholine release by presynaptic nicotinic receptors at developing neuromuscular synapses","volume":"51","author":"Fu W\u2010M.","year":"1997","journal-title":"Mol. 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