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The results indicate a benefit of thymectomy in early\u2010onset MG, but no obvious clinical benefit in late\u2010onset MG. The presence of muscle autoantibodies did not influence the outcome of thymectomy in early\u2010onset MG. In late\u2010onset MG, improvement is least likely in patients with titin and\/or RyR antibodies. Thymectomy should always be considered shortly after MG onset in early\u2010onset MG patients and might only be considered in late\u2010onset patients who have early\u2010onset\u2010like immunological characteristics.<\/jats:p>","DOI":"10.1196\/annals.1254.062","type":"journal-article","created":{"date-parts":[[2004,1,15]],"date-time":"2004-01-15T01:04:15Z","timestamp":1074128655000},"page":"481-490","source":"Crossref","is-referenced-by-count":16,"title":["Thymectomy and Antimuscle Antibodies in Nonthymomatous Myasthenia Gravis"],"prefix":"10.1111","volume":"998","author":[{"given":"FREDRIK","family":"ROMI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NILS E.","family":"GILHUS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAN E.","family":"VARHAUG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREAS","family":"MYKING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEIR O.","family":"SKEIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHAN A.","family":"AARLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00052-4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1990.tb05440.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90150-J"},{"key":"e_1_2_5_6_2","first-page":"55","article-title":"CA\u2010antibody: an immunological marker of thymic neoplasia in myasthenia gravis? 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