{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:17:35Z","timestamp":1761196655698},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Relaxin decreases oxytocin\u2010stimulated rat myometrial contractions <jats:italic>in vitro<\/jats:italic>. This study used pregnant relaxin\u2010deficient (<jats:italic>Rlx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in <jats:italic>Rlx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice than in <jats:italic>Rlx<\/jats:italic><jats:sup>+\/+<\/jats:sup> mice. An increase in ER\u03b1 in <jats:italic>Rlx<\/jats:italic><jats:sup>+\/+<\/jats:sup> mice at term was correlated with a decrease in ER\u03b2, which was not observed in <jats:italic>Rlx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice. Treatment of <jats:italic>Rlx<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice with relaxin had no effect on OTR, LGR7, or ER\u03b1 expression, but it caused a significant decrease in ER\u03b2s.<\/jats:p>","DOI":"10.1196\/annals.1282.014","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T09:26:55Z","timestamp":1118827615000},"page":"104-109","source":"Crossref","is-referenced-by-count":4,"title":["Oxytocin and Estrogen Receptor Expression in the Myometrium of Pregnant Relaxin\u2010Deficient (<i>Rlx<\/i><sup>\u2212\/\u2212<\/sup>) Mice"],"prefix":"10.1111","volume":"1041","author":[{"given":"ANDREW L.","family":"SIEBEL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HELEN M.","family":"GEHRING","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LENKA","family":"VODSTRCIL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAURA J.","family":"PARRY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.629"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-109-6-2076"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90942-3"},{"key":"e_1_2_5_5_2","first-page":"469","article-title":"Mechanisms regulating oxytocin receptor coupling to phospholipase C in rat and human myometrium","volume":"395","author":"Sanborn B.M.","year":"1995","journal-title":"Adv. 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