{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:27:02Z","timestamp":1758122822146},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> The actions of relaxin are highly species specific. The role of relaxin in human endometrial function has not been well understood because of the paucity of <jats:italic>in vivo<\/jats:italic> studies in women or in suitable primate models. A model of early human pregnancy was established in ovariectomized, steroid\u2010primed rhesus monkeys. Relaxin exerts dramatic uterine effects in this model, including a pronounced increase in uterine weight and stimulation of endometrial angiogenesis. In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases (MMP), causing decreased endometrial levels of MMP\u20101 and MMP\u20103 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1. This results in maintenance of endometrial collagen content. The negative effects of relaxin on MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix. Relaxin also significantly inhibits endometrial levels of estrogen receptor alpha and significantly inhibits levels of progesterone isoforms B and A. The findings that relaxin stimulates new blood vessel formation while maintaining endometrial connective tissue integrity are consistent with a significant role of relaxin in the establishment and\/or maintenance of early pregnancy.<\/jats:p>","DOI":"10.1196\/annals.1282.015","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T09:26:55Z","timestamp":1118827615000},"page":"110-117","source":"Crossref","is-referenced-by-count":5,"title":["Relaxin Regulates Endometrial Structure and Function in the Rhesus Monkey"],"prefix":"10.1111","volume":"1041","author":[{"given":"LAURA T.","family":"GOLDSMITH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GERSON","family":"WEISS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0013"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001190105"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-81-2-375"},{"key":"e_1_2_12_5_2","unstructured":"Tseng L. & B. Lane. 1995. Role of relaxin in the decidualization of human endometrial cells.InProgress in Relaxin Research: Proceedings of the Second International Congress on the Hormone Relaxin. A.H. MacLennan G.W. Tregear & G.D. Bryant\u2010Greenwood Eds. Chapter23.World Scientific Publishing Co. Singapore."},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400776101"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.6.1743"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.1.28"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021174"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.1.169"},{"key":"e_1_2_12_11_2","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.4049\/jimmunol.156.10.4027","article-title":"Endometrial T.B, and NK cells in patients with recurrent spontaneous abortion: altered profile and pregnancy outcome","volume":"156","author":"Lachapelle M.H.","year":"1996","journal-title":"J. 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