{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:32:09Z","timestamp":1767853929963,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Relaxin exhibits pleiotropic effects on reproductive and nonreproductive tissues; the signaling mechanisms underlying these functions are still not well understood. Activation of protein kinase A and several other signal\u2010regulated protein kinases results in the phosphorylation of phospholipase C (PLC)\u2010\u03b2<jats:sub>3<\/jats:sub> and inhibit G\u03b1<jats:sub>q<\/jats:sub>\u2010stimulated PLC activity. Therefore, PLC\u03b2<jats:sub>3<\/jats:sub> may be targeted by both contractant and relaxant signaling pathways in myometrium and play a critical role in the balance between them. PHM1 cells express mRNA for relaxin receptor LGR7, and relaxin inhibits oxytocin\u2010stimulated PLC activity in these cells. Thus, this model system may be useful in delineating signaling pathways used by relaxin. Here, we present evidence that relaxin stimulates phosphorylation of PLC\u03b2<jats:sub>3<\/jats:sub> in PHM1 cells.<\/jats:p>","DOI":"10.1196\/annals.1282.045","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T09:26:55Z","timestamp":1118827615000},"page":"300-304","source":"Crossref","is-referenced-by-count":6,"title":["Pathways Used by Relaxin to Regulate Myometrial Phospholipase C"],"prefix":"10.1111","volume":"1041","author":[{"given":"MIAO","family":"ZHONG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHUN\u2010YING","family":"KU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARBARA M.","family":"SANBORN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03804.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/eph8602179"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.11.5165"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.13.12.1977"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.2.605"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(03)00136-9"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021862"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122600302"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.29.18023"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006266200"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004276200"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.104203"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0013"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0284"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(03)00078-9"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1282.045","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1282.045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T09:08:02Z","timestamp":1695632882000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1282.045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1196\/annals.1282.045"],"URL":"https:\/\/doi.org\/10.1196\/annals.1282.045","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}