{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:34:56Z","timestamp":1773675296576,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> For the first time, the adenylate cyclase signaling mechanism (ACSM) of the action of relaxin H2 was revealed and deciphered in human and rat muscle tissues. The comparative study of signaling blocks forming the ACSM of relaxin and insulin (discovered earlier) showed that the postreceptor signaling chain of relaxin coincides with that of insulin. However, the type of relaxin receptor involved in ACSM remains obscure. Currently, the ACSM of relaxin may be represented as a signaling cascade: receptor \u21d2 Gi protein (\u03b2\u03b3\u2010dimer) \u21d2 phosphatidylinositol 3\u2010kinase (PI3K) \u21d2 protein kinase C\u03b6 (PKC\u03b6) \u21d2 Gs protein \u21d2 adenylate cyclase.<\/jats:p>","DOI":"10.1196\/annals.1282.046","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T09:26:55Z","timestamp":1118827615000},"page":"305-307","source":"Crossref","is-referenced-by-count":11,"title":["A Novel, Adenylate Cyclase, Signaling Mechanism of Relaxin H2 Action"],"prefix":"10.1111","volume":"1041","author":[{"given":"ALEXANDER","family":"SHPAKOV","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIANNA","family":"PERTSEVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUDMILA","family":"KUZNETSOVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SVETLANA","family":"PLESNEVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00592-5"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-4959(02)00160-4"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00007-5"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065654"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.9.799"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1282.046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1282.046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T09:08:04Z","timestamp":1695632884000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1282.046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1196\/annals.1282.046"],"URL":"https:\/\/doi.org\/10.1196\/annals.1282.046","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}