{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:02:10Z","timestamp":1761894130989},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>:<\/jats:bold>Perineal hernia occurs spontaneously in older male dogs after idiopathic weakening of the pelvic diaphragm. Hernias invariably contain cystic paraprostatic tissues. Castration reduces incidence and recurrence after surgical repair. Although cystic prostatic hypertrophy is a consistent feature in patients with perineal hernia, an endocrine link of the disease to steroid sex hormones has not been demonstrated. Employing immunohistochemistry, we found intense relaxin immunoreactivity in dogs with perineal hernia within the epithelia of hypertrophic prostates and in periprostatic tissues. The prostate of normal dogs exhibited similar but less intense relaxin staining. In neutered dogs with prostatic atrophy, relaxin immunostaining was weak or absent. Periprostatic cysts highly expressed relaxin precursors in the fluid phase as shown by SDS\u2010gel electrophoresis. Relaxin of prostatic origin, therefore, is possibly a local factor in connective tissue weakening and subsequently in perineal hernia formation.<\/jats:p>","DOI":"10.1196\/annals.1282.062","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T09:26:55Z","timestamp":1118827615000},"page":"415-422","source":"Crossref","is-referenced-by-count":31,"title":["Relaxin of Prostatic Origin Might Be Linked to Perineal Hernia Formation in Dogs"],"prefix":"10.1111","volume":"1041","author":[{"given":"GERT W.","family":"NIEBAUER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SARINA","family":"SHIBLY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MONIKA","family":"SELTENHAMMER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ARMIN","family":"PIRKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SABINE","family":"BRANDT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Bellenger C.R. & R.B. Canfield. 2003. Perineal hernia.InTextbook of Small Animal Surgery 3rdEd. D. Slatter Ed. :487\u2010498 W.B. Saunders. Philadelphia PA."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-31-4-331"},{"key":"e_1_2_5_4_2","first-page":"1578","article-title":"Serum testosterone and estradiol 17\u2010beta concentrations in 15 dogs with perineal hernia","volume":"194","author":"Mann F.A.","year":"1989","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2460\/ajvr.1995.56.01.134","article-title":"Androgen receptors in the pelvic diaphragm muscles of dogs with and without perineal hernia","volume":"56","author":"Mann F.A.","year":"1995","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_5_6_2","unstructured":"Niebauer G.W. C. Ritter & B. Wolf. 1991. The potential role of relaxin in canine perineal hernia.InProceedings of the 75thAnnual Meeting of the Federation of American Societies for Experimental Biology St. Louis MI Abstr. 7364."},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","unstructured":"Merchav R. R. Shahar D.E. Johnston et al.2004. The expression of relaxin receptor LRG7 canine relaxin and relaxin\u2010like factor in the pelvic diaphragm musculature of dogs with and without perineal hernia. In press.","DOI":"10.1111\/j.1532-950X.2005.00072.x"},{"key":"e_1_2_5_8_2","first-page":"614","article-title":"A possible association between acquired nontraumatic inguinal and perineal hernia in adult male dogs","volume":"37","author":"Shahar R.","year":"1996","journal-title":"Can. Vet. J."},{"key":"e_1_2_5_9_2","unstructured":"Adham I.M. 2004. INSL3\u2010mediated activity is responsible for testis decent. 4thInternational Conference on Relaxin and Related Peptides Moran WY September 5\u201010 Abstr. 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