{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T23:03:20Z","timestamp":1711407800188},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T00:00:00Z","timestamp":1138060800000},"content-version":"vor","delay-in-days":785,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> 5\u03b1\u2010pregnan\u20103\u03b1\u2010ol\u201020\u2010one (3\u03b1,5\u03b1\u2010THP) in the ventral tegmental area (VTA) mediates lordosis of rodents. If fluoxetine's effects on lordosis are mediated in part by midbrain 3\u03b1,5\u03b1\u2010THP, then fluoxetine regimens that decrease and increase lordosis would be expected to respectively lower and elevate midbrain 3\u03b1,5\u2010THP levels. <jats:italic>Experiment 1:<\/jats:italic> Ovariectomized (ovx) rats received estradiol benzoate (EB; 5 \u03bcg, SC) at 0 and 24 h and fluoxetine (20 mg\/kg, IP) or vehicle 30 min before sex testing and tissue collection. Other rats received fluoxetine (10 mg\/kg, IP) or vehicle for 15 days followed by EB\u2010priming and testing. Systemic acute or chronic fluoxetine significantly decreased lordosis and midbrain 3\u03b1,5\u03b1\u2010THP levels compared to vehicle. <jats:italic>Experiment 2:<\/jats:italic> Ovx rats with unilateral cannula to the VTA were primed with EB (5 \u03bcg; 0, 24 h) and\/or progesterone (0 or 100 \u03bcg; 44 h, SC). At 47.5 h, fluoxetine (3.6 mM) or vehicle was infused to the VTA. At 48 h, rats were tested. Administering fluoxetine to the VTA significantly increased lordosis and midbrain 3\u03b1,5\u03b1\u2010THP levels compared to vehicle infusions. <jats:italic>Experiment 3:<\/jats:italic> Ovx EB\u2010primed rats were tested prior to, and 30 min after, treatmemt with acute fluoxetine (20 mg\/kg, IP). Rats were then infused with 3\u03b1,5\u03b1\u2010THP (100 ng) or vehicle to the VTA and were retested. 3\u03b1,5\u03b1\u2010THP, but not vehicle, to the VTA reversed acute fluoxetine's inhibitory effects on lordosis. Together, these data suggest fluoxetine may alter lordosis in part through actions of 3\u03b1\u2010THP in the midbrain.<\/jats:p>","DOI":"10.1196\/annals.1286.004","type":"journal-article","created":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T18:44:28Z","timestamp":1078166668000},"page":"37-41","source":"Crossref","is-referenced-by-count":25,"title":["Fluoxetine May Influence Lordosis of Rats through Effects on Midbrain 3\u03b1,5\u03b1\u2010THP Concentrations"],"prefix":"10.1111","volume":"1007","author":[{"given":"CHERYL A.","family":"FRYE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANDRA M.","family":"PETRALIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MADELINE E.","family":"RHODES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BENJAMIN","family":"STEIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00119-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(91)90036-H"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90515-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00367.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00379.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343590"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.5.1118"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00109-6"},{"key":"e_1_2_6_10_2","unstructured":"Zanisi M. et al. 1984. In Metabolism of Hormonal Steroids in the Neuroendocrine Structures. F. Celotti Ed.: 171\u2013182. Raven Press. New York."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300051"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00040-2"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13512"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100853"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.22.12599"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3239"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00129-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02373-8"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(00)00098-4"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200210000-00013"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1001\/jama.1995.03520430025019","article-title":"Fluoxetine and sexual dysfunction","volume":"273","author":"Baylon R.","year":"1995","journal-title":"JAMA"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1286.004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1286.004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T22:37:37Z","timestamp":1695681457000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1286.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1196\/annals.1286.004"],"URL":"https:\/\/doi.org\/10.1196\/annals.1286.004","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}