{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T01:10:02Z","timestamp":1695690602190},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T00:00:00Z","timestamp":1138060800000},"content-version":"vor","delay-in-days":815,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Background\u2014There is controversy about the way the \u03b2 cell mass is reduced in type 1 diabetes. One view is that a gradual fall in \u03b2 cell mass begins soon after the onset of insulitis. Another view is that a sudden wave of \u03b2 cell destruction occurs just before the onset of diabetes. To clarify how the \u03b2 cell mass is reduced, we performed adoptive transfer experiments and examined the relationship between the pancreatic status of NOD donors and the time taken to transfer diabetes into NOD\u2010scid recipients. Methods\u2014We killed 18\u2010week\u2010old female NOD mice (<jats:styled-content><jats:italic>n<\/jats:italic>= 20<\/jats:styled-content>), removed their spleen, and transferred splenocytes into 5\u2010week\u2010old female NOD\u2010scid mice (<jats:styled-content><jats:italic>n<\/jats:italic>= 60<\/jats:styled-content>). The relationship between the pancreatic status of donors and the time taken to transfer diabetes into recipients was assessed. As pancreatic status, we measured insulin content and severity of insulitis. Results\u2014There was no linear correlation between the pancreatic status of donors and the time taken to transfer diabetes into recipients. NOD donors who needed 7 or more weeks to transfer diabetes in NOD\u2010scid recipients had similar levels of insulin content or severity of insulitis as those of NOD donors who could not transfer diabetes. On the other hand, NOD donors who needed 6 or less weeks to transfer diabetes in recipients had similar levels of insulin content or severity of insulitis as those of diabetic NOD mice. Conclusions\u2014According to our observations, \u03b2 cell mass seems to be preserved until just before the onset of diabetes and decreased dramatically within a few weeks.<\/jats:p>","DOI":"10.1196\/annals.1288.028","type":"journal-article","created":{"date-parts":[[2004,1,12]],"date-time":"2004-01-12T17:32:48Z","timestamp":1073928768000},"page":"211-214","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between \u03b2 Cell Mass of NOD Donors and Diabetes Development of NOD\u2010scid Recipients in Adoptive Transfer System"],"prefix":"10.1111","volume":"1005","author":[{"given":"SATORU","family":"YAMADA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AKIRA","family":"SHIMADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEIICHI","family":"KODAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIRO","family":"MORIMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RYUJI","family":"SUZUKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOICHI","family":"OIKAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JUNICHIRO","family":"IRIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKAO","family":"SARUTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012350"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605223142106"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.45.8.1063"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-15-9-1089"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2337\/diab.44.5.550","article-title":"Islet\u2010infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD\u2010scid\/scid mice","volume":"44","author":"Rohane P.W.","year":"1995","journal-title":"Diabetes"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1288.028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1288.028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:48:56Z","timestamp":1695689336000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1288.028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1196\/annals.1288.028"],"URL":"https:\/\/doi.org\/10.1196\/annals.1288.028","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}