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Understanding the mechanisms that regulate insulin secretion may allow the development of new therapies for these diseases as well as contribute to our ability to engineer insulin\u2010producing cells for cell replacement therapy of type 1 diabetes. Glucose phosphorylation in \u03b2\u2010cells has been viewed as a key regulatory event in coupling insulin secretion to extracellular glucose concentrations. Work with transformed rodent \u03b2\u2010cell lines as well as recent findings from human progenitor cells induced to differentiate into insulin\u2010producing cells has provided new insights into the role of glucose phosphorylating enzymes in the regulation of insulin secretion.<\/jats:p>","DOI":"10.1196\/annals.1294.009","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T01:39:59Z","timestamp":1085103599000},"page":"88-96","source":"Crossref","is-referenced-by-count":23,"title":["Regulation of Insulin Secretion: Insights from Engineered \u03b2\u2010cell Lines"],"prefix":"10.1111","volume":"1014","author":[{"given":"SHIMON","family":"EFRAT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Rhodes C.J. 2000. 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