{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:01:09Z","timestamp":1791039669961,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":651,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Malignant carcinoid tumors express high numbers of somatostatin receptors. Radiation therapy using labeled somatostatin analogs is a novel treatment modality for these tumors. We have analyzed the biokinetics and therapeutic effect of radiolabeled somatostatin analog on a human midgut carcinoid grafted to nude mice. A transplantable human midgut carcinoid (GOT1) was grafted to the back of nude mice. Tumor\u2010bearing mice were injected with <jats:sup>111<\/jats:sup>In\u2010DTPA\u2010D\u2010Phe<jats:sup>1<\/jats:sup>\u2010octreotide, followed by measurement of <jats:sup>111<\/jats:sup>In activity concentration ratios in tumor tissues. Tumor\u2010bearing mice were also injected with <jats:sup>177<\/jats:sup>Lu\u2010DOTA\u2010Tyr<jats:sup>3<\/jats:sup>\u2010octreotate and followed for 7 days. The concentration of <jats:sup>111<\/jats:sup>In\u2010DTPA\u2010D\u2010Phe<jats:sup>1<\/jats:sup>\u2010octreotide in tumor tissues was very high 4 hours postinjection with 0.4\u201313% of injected activity per gram. Injection of 30\u2013120 MBq <jats:sup>177<\/jats:sup>Lu\u2010DOTA\u2010Tyr<jats:sup>3<\/jats:sup>\u2010octreotate reduced tumor volume to 7\u201314% of the original tumor volume 7 days postinjection. Microscopic analysis of treated tumors revealed widespread areas of tumor cell necrosis and fibrosis. It was found that grafted GOT1 cells to nude mice represent an authentic model for studying human midgut carcinoids. Radiolabeled somatostatin analogs have a high selectivity for tumor tissue and can induce tumor cell necrosis. Radiotherapy of carcinoid tumors with <jats:sup>177<\/jats:sup>Lu\u2010DOTA\u2010Tyr<jats:sup>3<\/jats:sup>\u2010octreotate appears to be a promising treatment modality for either palliative treatment or completion therapy after attempted surgical cure.<\/jats:p>","DOI":"10.1196\/annals.1294.031","type":"journal-article","created":{"date-parts":[[2004,5,21]],"date-time":"2004-05-21T01:39:59Z","timestamp":1085103599000},"page":"275-279","source":"Crossref","is-referenced-by-count":15,"title":["GOT1 Xenografted to Nude Mice: A Unique Model for <i>in Vivo<\/i> Studies on SSTR\u2010Mediated Radiation Therapy of Carcinoid Tumors"],"prefix":"10.1111","volume":"1014","author":[{"given":"OLA","family":"NILSSON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LARS","family":"K\u00d6LBY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER","family":"BERNHARDT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EVA","family":"FORSSELL\u2010ARONSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VIKTOR","family":"JOHANSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00c5KAN","family":"AHLMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900136"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6630-z"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841869309083921"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051862"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01589.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4149"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64017-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(02)00417-1"},{"key":"e_1_2_6_10_2","first-page":"7","article-title":"Indium\u2010111 activity concentration in tissue samples after intravenous injection of indium\u2010111\u2010DTPA\u2010D\u2010Phe\u20101\u2010octreotide","volume":"36","author":"Forssell\u2010Aronsson E.","year":"1995","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_11_2","first-page":"1841","article-title":"Tumor response after [(90)Y\u2010DOTA(0), Tyr(3)]octreotide radionuclide therapy in a transplantable rat tumor model is dependent on tumor size","volume":"42","author":"Jong M.","year":"2001","journal-title":"J. Nucl. 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