{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:31:09Z","timestamp":1791156669076,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T00:00:00Z","timestamp":1137369600000},"content-version":"vor","delay-in-days":594,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> The ability of serotonin (5\u2010HT) to facilitate or attenuate autonomic, endocrine, and behavioral responses to stressful stimuli has received much attention. The effects of 5\u2010HT on physiologic and behavioral responses to stressful stimuli seem to depend on the brain region where it is released and the effector system it acts upon. This and the distinct morphology and topographic organization of subpopulations of serotonergic neurons have led to the hypothesis that subpopulations of serotonergic neurons are functionally distinct. Serotonin's role as a modulator of the \u201cfight\u2010or\u2010flight\u201d response is mediated in part by 5\u2010HT release in the dorsolateral periaqueductal gray (DLPAG) and in the rostral ventrolateral medulla (RVLM), an area that contains sympathoexcitatory C1 adrenergic (A) neurons. The release of 5\u2010HT in either region inhibits stress\u2010induced sympathetic activity in part via actions on 5\u2010HT<jats:sub>1A<\/jats:sub> receptors. In addition, 5\u2010HT release in the DLPAG inhibits fight\u2010or\u2010flight or \u201cGo\u201d behaviors. The origin of endogenous 5\u2010HT in the DLPAG and RVLM seems to be a subpopulation of serotonergic neurons within the ventrolateral PAG, a region implicated in \u201cfreezing\u201d or \u201cNo Go\u201d behaviors. These serotonergic neurons are located in the lateral \u201cwings\u201d of the dorsal raphe nucleus (DRN) a region also referred to as the ventrolateral DRN. The existence of a functional subpopulation of serotonergic neurons capable of inhibiting sympathoexcitation and fight\u2010or\u2010flight behavioral responses may be clinically relevant for explaining in part the efficacy of serotonergic drugs in the treatment of hypertension and panic attacks in panic disorder patients.<\/jats:p>","DOI":"10.1196\/annals.1296.006","type":"journal-article","created":{"date-parts":[[2004,7,7]],"date-time":"2004-07-07T20:59:19Z","timestamp":1089233959000},"page":"58-64","source":"Crossref","is-referenced-by-count":87,"title":["A Functional Subset of Serotonergic Neurons in the Rat Ventrolateral Periaqueductal Gray Implicated in the Inhibition of Sympathoexcitation and Panic"],"prefix":"10.1111","volume":"1018","author":[{"given":"PHILIP L.","family":"JOHNSON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STAFFORD L.","family":"LIGHTMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTOPHER A.","family":"LOWRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60812-1"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00655-6"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02135-3"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-20-07728.2000"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(96)00059-0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2002.00861.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/026988119701100111"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245294"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00785-7"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1969.30.1.0014"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.4.R976"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03764-2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00451-0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00464-3"},{"key":"e_1_2_7_16_2","first-page":"R1063","article-title":"Lesions of the C1 catecholaminergic neurons of the ventrolateral medulla in rats using anti\u2010DbetaH\u2010saporin","volume":"277","author":"Madden C.J.","year":"1999","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02811-1"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(99)00021-1"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01181-6"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)11788-K"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970310)379:2<261::AID-CNE7>3.0.CO;2-1"},{"key":"e_1_2_7_22_2","first-page":"69","article-title":"The control of brain tryptophan concentration","volume":"29","author":"Curzon G.","year":"1975","journal-title":"Acta Vitaminol. Enzymol."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(73)90361-5"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00117-7"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(02)00262-7"},{"key":"e_1_2_7_26_2","unstructured":"Paxinos G. & C. Watson. 1997. The Rat Brain Stereotaxic Coordinates. Academic Press. San Diego CA."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1296.006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1296.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T22:49:39Z","timestamp":1695682179000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1296.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1196\/annals.1296.006"],"URL":"https:\/\/doi.org\/10.1196\/annals.1296.006","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}