{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:16:56Z","timestamp":1762100216861},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T00:00:00Z","timestamp":1137369600000},"content-version":"vor","delay-in-days":594,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Cold\u2010restraint stress reduces gastric blood flow and produces acute gastric ulcers. We studied the role of Angiotensin II (Ang II) on gastric blood flow and gastric ulceration during stress. Spontaneously hypertensive rats, a stress\u2010sensitive strain, were pretreated for 14 days with the AT<jats:sub>1<\/jats:sub> receptor antagonist candesartan before cold\u2010restraint stress. AT<jats:sub>1<\/jats:sub> blockade increased gastric blood flow 40% to 50%; prevented gastric ulcer formation by 70% to 80%; reduced the increase in adrenomedullary epinephrine and TH mRNA without preventing the stress\u2010induced increase in adrenal corticosterone; decreased the stress\u2010induced expression of tumor necrosis factor \u03b1 (TNF\u2010\u03b1) and adhesion protein ICAM\u20101 in arterial endothelium, and neutrophil infiltration in the gastric mucosa; and decreased PGE<jats:sub>2<\/jats:sub> content. AT<jats:sub>1<\/jats:sub> receptor blockers prevent stress\u2010induced ulcerations by a combination of gastric blood flow protection, decreased sympathoadrenal activation, anti\u2010inflammatory effects with reduction in TNF\u2010\u03b1, and ICAM\u20101 expression, leading to reduced neutrophil infiltration while maintaining the protective glucocorticoid effects and PGE<jats:sub>2<\/jats:sub> release. Ang II has a crucial role, through stimulation of AT<jats:sub>1<\/jats:sub> receptors, in the production and progression of stress\u2010induced gastric injury, and AT<jats:sub>1<\/jats:sub> receptor antagonists could be of therapeutic benefit.<\/jats:p>","DOI":"10.1196\/annals.1296.044","type":"journal-article","created":{"date-parts":[[2004,7,7]],"date-time":"2004-07-07T20:59:19Z","timestamp":1089233959000},"page":"351-355","source":"Crossref","is-referenced-by-count":22,"title":["Angiotensin II AT<sub>1<\/sub> Receptor Blockade Prevents Gastric Ulcers during Cold\u2010Restraint Stress"],"prefix":"10.1111","volume":"1018","author":[{"given":"C","family":"BREGONZIO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"ARMANDO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"ANDO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"JEZOVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"BAIARDI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"SAAVEDRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31970"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb11191.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-13-2-329"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109488"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118623"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.9.8366"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000027274.03779.F3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-5-1730"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.1.H108"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","unstructured":"Bregonzio C. I. Armando H. Ando et al.2003. Anti\u2010inflammatory effects of Angiotensin II AT1receptor antagonism prevent stress\u2010induced gastric injury. Am. J. Physiol. Gastrointest. Liver Physiol.285:G414\u2010423. 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