{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:42:24Z","timestamp":1762504944322},"reference-count":76,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T00:00:00Z","timestamp":1137369600000},"content-version":"vor","delay-in-days":594,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> In today's psychiatry there is a great deal of interest in the development of compounds with a novel mechanism of action that diverge from the classical catecholaminergic neurotransmitter system targets. Within the last few years, it has become increasingly evident that the neuroendocrine and behavioral phenotypes of mood and anxiety disorders are at least in part mediated by modulation of corticotropin\u2010releasing hormone (CRH) neurocircuitries and that normalization of an altered neurotransmission after treatment may lead to restoration of disease\u2010related changes. Although this concept was originally derived from peripheral hypothalamic\u2010pituitary\u2010adrenocortical (HPA) assessments in depressed patients, central CRH neuropeptidergic circuits other than those driving the peripherally accessible HPA system may be overactive and could be therapeutic targets of antagonist actions. Genetically engineered mice provide a novel and useful tool to study the endogenous mechanisms underlying aberrant behavior and CRH neurocircuitry regulation. The results obtained from conventional and conditional mutant mice indicate that CRH type 1 receptors may be the primary target to which to direct selective nonpeptide compounds. Moreover, beyond the encouraging preclinical studies, the first clinical open trial supports the notion that CRH type 1 receptors can be safely and effectively antagonized.<\/jats:p>","DOI":"10.1196\/annals.1296.055","type":"journal-article","created":{"date-parts":[[2004,7,7]],"date-time":"2004-07-07T20:59:19Z","timestamp":1089233959000},"page":"445-457","source":"Crossref","is-referenced-by-count":20,"title":["Mouse Mutants for the Study of Corticotropin\u2010Releasing Hormone Receptor Function: Development of Novel Treatment Strategies for Mood Disorders"],"prefix":"10.1111","volume":"1018","author":[{"given":"MARTIN E.","family":"KECK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FLORIAN","family":"HOLSBOER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIANNE B.","family":"M\u00dcLLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,16]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0065-1591.2000.acp29-02.x"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.10.1568"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07492-2"},{"key":"e_1_2_3_5_2","first-page":"26","article-title":"The burden of disease for treatment\u2010resistant depression","volume":"62","author":"Greden J.F.","year":"2001","journal-title":"J. Clin. Psychiatry"},{"key":"e_1_2_3_6_2","first-page":"16","article-title":"The use of antidepressant drugs in patients with heart disease","volume":"59","author":"Glassman A.H.","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.7.580"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70369-8"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80155-6"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(98)90056-5"},{"key":"e_1_2_3_11_2","first-page":"4","article-title":"Pharmacology of antidepressants: selectivity or multiplicity? J","volume":"60","author":"Westenberg H.G.","year":"1999","journal-title":"Clin. Psychiatry"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200304000-00008"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00398-9"},{"key":"e_1_2_3_14_2","first-page":"46","article-title":"Corticotropin\u2010releasing hormone modulators and depression","volume":"4","author":"Holsboer F.","year":"2003","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1998.00254.x"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000123454"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.130.6.1597149"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(97)00030-9"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-05-02579.1994"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02245.x"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(01)00117-5"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/378287a0"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051626398"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121165198"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/87936"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-10-06340.1995"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(95)00099-W"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00682-9"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5281.1561"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/74255"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(96)81594-X"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.5.8612563"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.836"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00747-1"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00624.x"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<1::AID-CNE1>3.0.CO;2-6"},{"key":"e_1_2_3_37_2","first-page":"307","article-title":"Localization of urocortin messenger RNA in rat brain and pituitary","volume":"1","author":"Wong M.L.","year":"1998","journal-title":"Mol. Psychiatry"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00071-8"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00732-5"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng914"},{"key":"e_1_2_3_41_2","first-page":"71","article-title":"Physiological and behavioral responses to corticotropin\u2010releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res","volume":"15","author":"Dunn A.J.","year":"1990","journal-title":"Rev."},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050645"},{"key":"e_1_2_3_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816X.2000.01383.x"},{"key":"e_1_2_3_44_2","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1995.1013"},{"key":"e_1_2_3_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199705060-00027"},{"key":"e_1_2_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(98)00160-0"},{"key":"e_1_2_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991220)415:3<285::AID-CNE1>3.0.CO;2-0"},{"key":"e_1_2_3_48_2","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1523\/JNEUROSCI.20-03-01240.2000","article-title":"Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin\u2010releasing factor and urocortin neuronal systems","volume":"20","author":"Skelton K.H.","year":"2000","journal-title":"J. Neurosci."},{"key":"e_1_2_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(01)00046-X"},{"key":"e_1_2_3_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-12-05016.1999"},{"key":"e_1_2_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02707-5"},{"key":"e_1_2_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80491-2"},{"key":"e_1_2_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/520"},{"key":"e_1_2_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(98)00064-7"},{"key":"e_1_2_3_55_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0080151"},{"key":"e_1_2_3_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069836"},{"key":"e_1_2_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00097-6"},{"key":"e_1_2_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00475-4"},{"key":"e_1_2_3_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/74263"},{"key":"e_1_2_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/74271"},{"key":"e_1_2_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)20022-0"},{"key":"e_1_2_3_62_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.11.8507"},{"key":"e_1_2_3_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00193.2002"},{"key":"e_1_2_3_64_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38092"},{"key":"e_1_2_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(02)00299-3"},{"key":"e_1_2_3_66_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.042788"},{"key":"e_1_2_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00010-1"},{"key":"e_1_2_3_68_2","doi-asserted-by":"publisher","DOI":"10.1159\/000124986"},{"key":"e_1_2_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(02)00009-2"},{"key":"e_1_2_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(00)00016-9"},{"key":"e_1_2_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(03)00070-0"},{"key":"e_1_2_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(03)00076-1"},{"key":"e_1_2_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00159-7"},{"key":"e_1_2_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(01)00049-8"},{"key":"e_1_2_3_75_2","doi-asserted-by":"publisher","DOI":"10.1054\/npep.2002.0896"},{"key":"e_1_2_3_76_2","unstructured":"Keck M.E. F. Ohl F. Holsboer & M.B. M\u00fcller. 2004. Listening to mutant mice: the role of CRH\/CRH receptor systems in affective disorders. Neurosci. Biobehav. Rev. In press."},{"key":"e_1_2_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1123"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1296.055","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1296.055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T22:50:30Z","timestamp":1695682230000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1296.055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1196\/annals.1296.055"],"URL":"https:\/\/doi.org\/10.1196\/annals.1296.055","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}