{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:22:51Z","timestamp":1700544171072},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":590,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> The expression levels of GAP\u201043 and MAP\u20102, two proteins involved, respectively, in axonal and dendritic remodeling, in control adult (11 months), old (24 months), and vitamin E\u2010deficient (11 months) rats were evaluated. mRNA levels were determined by means of a quantitative <jats:italic>in situ<\/jats:italic> hybridization procedure in subregions of hippocampus and cerebellum. Though a general trend can be observed indicating a reduction in GAP\u201043 expression in aging as compared to adult animals and an increase in vitamin E\u2010deprived rats in comparison with adult animals, no statistically significant change was found in any region analyzed. In the same way, MAP\u20102 mRNA levels show an increase in vitamin E\u2010deprived rats in comparison with other groups tested; only one variation was statistically significant, namely the increase in cerebellar cortex MAP\u20102 nRNA levels in vitamin E\u2010deficient versus adult rats. These results suggest that oxidative stress and aging negatively affect neuroplasticity, showing different characteristics at the dendritic and axonal levels.<\/jats:p>","DOI":"10.1196\/annals.1297.008","type":"journal-article","created":{"date-parts":[[2004,7,10]],"date-time":"2004-07-10T21:39:14Z","timestamp":1089495554000},"page":"37-40","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin E Deficiency and Aging Effect on Expression Levels of GAP\u201043 and MAP\u20102 in Selected Areas of the Brain"],"prefix":"10.1111","volume":"1019","author":[{"given":"TIZIANA","family":"CASOLI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIUSEPPINA","family":"DI STEFANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALESSIA","family":"DELFINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PATRIZIA","family":"FATTORETTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CARLO","family":"BERTONI\u2010FREDDARI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10072-2"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00046-5"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199906000-00008"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90117-2"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01504-3"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900818"},{"key":"e_1_2_2_8_2","unstructured":"Di Stefano G. T. Casoli P. Fattoretti et al.2002. Effect of vitamin E\u2010deficiency and aging on MAP\u20102 and GAP\u201043 distribution in rat hippocampus. Free Radical Res.36(Suppl. 1): 61\u201062."},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90170-5"},{"key":"e_1_2_2_10_2","doi-asserted-by":"crossref","unstructured":"Cadete\u2010Leite A. M.A. Tavares M.M. Pacheco et al.1989. Hippocampal mossy fiber\u2014CA3 synapses after chronic alcohol consumption and withdrawal. Alcohol 6: 303\u2010310.","DOI":"10.1016\/0741-8329(89)90087-6"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1297.008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1297.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T21:05:39Z","timestamp":1696799139000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1297.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1196\/annals.1297.008"],"URL":"https:\/\/doi.org\/10.1196\/annals.1297.008","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}