{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:07:51Z","timestamp":1790849271496,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":590,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Peculiarities of functioning of some parts of the endocrine system (the pineal gland, pancreatic gland, hypothalamic\u2010pituitary\u2010adrenal axis, and hypothalamic\u2010pituitary\u2010testicular axis) in an aging nonhuman primate model (<jats:italic>Papio hamadryas<\/jats:italic> and <jats:italic>Macaca mulatta<\/jats:italic>) are described in this article. It has been established that basal activity of some endocrine functions (glucocorticoid, corticotropic, pancreatic, male estradiol producing) varies little with age. Other functions significantly decrease (DHEA\/DHEAS\u2010producing, pineal, testicular) or increase (male gonadotropic) with age. In contrast with basal activity, pronounced age\u2010related changes in response to specific stimuli were detected in all endocrine functions. Old baboons and rhesus monkeys exhibited a delay of the normalization of the pituitary\u2010testicular axis, adrenal cortex, and pancreatic gland function after their activation in response to specific stimuli, such as LHRH, CRH, ACTH, and glucose. Old monkeys also demonstrate decreased HPA axis sensitivity to glucocorticoid regulation by negative feedback and the HPT axis to inhibitory effect of prolonged administration of LHRH agonist. Age\u2010related changes in reactions of endocrine functions in response to specific stimulating and inhibiting stimuli indicate impaired resiliency of these functions. Age\u2010related endocrine changes perhaps play a pathophysiological role in age function disorders of hormonocompetent tissues and organs and age pathology.<\/jats:p>","DOI":"10.1196\/annals.1297.054","type":"journal-article","created":{"date-parts":[[2004,7,10]],"date-time":"2004-07-10T21:39:14Z","timestamp":1089495554000},"page":"321-325","source":"Crossref","is-referenced-by-count":24,"title":["Age\u2010Related Endocrine Dysfunction in Nonhuman Primates"],"prefix":"10.1111","volume":"1019","author":[{"given":"N D.","family":"GONCHAROVA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A.","family":"LAPIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"44","article-title":"Zh","volume":"33","author":"Goncharova N.D.","year":"1997","journal-title":"Evolyuts. Biokhim. 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