{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:18:01Z","timestamp":1758709081873},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":590,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Distress and senescence, their reciprocal aggravating\u2010quickening connections, and their related pathologies have a large worldwide impact on healthcare systems in this new millennium. For this reason, Antagonic\u2010Stress\u00ae (AS)\u2014an advanced integrative therapy, with specific synergistic composition, and patented internationally\u2014represents a significant strategy in health, aging, and longevity. Clinical research with AS proves the drug's efficacy in the management of distress (neurotic, stress\u2010related, and affective disorders; behavioral syndromes associated with physiological disturbances and physical factors; mental and behavioral disorders due to psychoactive substance uses) and psychogeriatrics [organic, including symptomatic, mental disorders (OMD)]. Specific multiaxial psychopathological instruments and psychometric tests in multiple assessments used for gerontopsychiatry demonstrated strong improvements after AS administration in early\u2010moderate stages of Alzheimer or vascular dementia, as well as in other OMD. In addition, comparative clinical studies evinced the superiority of AS (synergistic multitherapy) versus monotherapy [meclofenoxate (MF), piracetam (PA), pyritinol (PT), and nicergoline (NE), respectively]. These comparative clinical trials agreed closely with comparative preclinical research and confirmed AS synergistic homeostatic, adaptogenic, antioxidative, cerebrovascular, neurometabolic, and nootropic actions. Also, the AS protective actions against oxidative stress recommend this orthomolecular therapy in stress, aging, and free radical pathology.<\/jats:p>","DOI":"10.1196\/annals.1297.072","type":"journal-article","created":{"date-parts":[[2004,7,10]],"date-time":"2004-07-10T21:39:14Z","timestamp":1089495554000},"page":"401-405","source":"Crossref","is-referenced-by-count":1,"title":["Prolongevity Medicine: Antagonic\u2010Stress\u00ae Drug in Distress, Geriatrics, and Related Diseases. II. Clinical Review\u20142003"],"prefix":"10.1111","volume":"1019","author":[{"given":"S","family":"RIGA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"RIGA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"SCHNEIDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02115.x"},{"key":"e_1_2_6_3_2","unstructured":"Riga D. & S. Riga. 1998\u20102004. Twenty\u2010five patents worldwide of the Antagonic\u2010Stress\u00ae drug: AU Pat. (1998) KR Pat. (1999) EUR Pat. (1999) for 16 Eur. States RU Pat. (2000) US Pat. (2001) CN Pat. (2001) RO Pat. (2001) CA Pat. (2002) JP Pat. (2003) and BR Pat. (2004)."},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","unstructured":"Riga D. S. Riga & F. Schneider. 2003. Regenerative medicine: Antagonic\u2010Stress\u00ae therapy in distress and aging. I. Preclinical synthesis\u20142003. Biogerontology4(Suppl. 1): 81.","DOI":"10.1196\/annals.1297.071"},{"key":"e_1_2_6_5_2","unstructured":"Riga S. & D. Riga. 1998. Nootropic antioxidative therapy in stress aging and related disorders. II. Clinical review\u20141998. 2nd World Congress Stress. Melbourne Australia."},{"key":"e_1_2_6_6_2","unstructured":"Riga S. & D. Riga. 2000. Modern therapies of anti\u2010stress and anti\u2010aging cerebral activation.InTextbook of Mental Health. Vol. 1. D. Prelipceanu R. Mihailescu & R. Teodorescu Eds.: 415\u2010440. Encyclopaedic Press. Bucharest Romania."},{"key":"e_1_2_6_7_2","unstructured":"Riga S. & D. Riga. 1997. Antagonic\u2010Stress\u00ae a new therapeutic system for anti\u2010aging anti\u2010impairment and anti\u2010stress management. 16th World Congress International Association of Gerontology (Aging beyond 2000: one world one future). Book of Abstracts Abst. 653: 215. Adelaide Australia."},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09926.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb12101.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","unstructured":"Popa R.et al.1994. Antagonic\u2010Stress superiority versus meclofenoxate in gerontopsychiatry (Alzheimer type dementia). Arch. Gerontol. Geriatr.19(Suppl. 4): 197\u2010206.","DOI":"10.1016\/S0167-4943(05)80065-2"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb12102.x"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1297.072","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1297.072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T21:05:28Z","timestamp":1696799128000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1297.072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1196\/annals.1297.072"],"URL":"https:\/\/doi.org\/10.1196\/annals.1297.072","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}