{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:27:41Z","timestamp":1761596861034},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":590,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> To test new treatment modalities, a pilot study with a novel noninvasive biophysical methodology (Delta\u2010S DVD) that can artificially exert a \u201cdecrease of entropy\u201d through the patented electromagnetic\u2010driven delivery of \u201cenergy clusters\u201d was designed. This process has been modulated and integrated by the body as a \u201cself\u201d source to support the energy\u2010dependent functional stores, thus modifying reparative into regenerative mechanisms of liver parenchyma. Seven long\u2010standing hepatitis C virus\u2010positive (Child A\u2010B) cirrhosis patients with overt symptoms and portal hypertension and failure or side effects of antiviral drug treatment underwent 40\u2010min sessions of Delta\u2010S DVD daily for six months and were followed up monthly. At the end of the first month, rapid improvement of symptoms and a decrease of portal hypertension were noted. At the end of treatment, all patients showed either a complete (80%) or a partial (20%) regression of fatigue (FISK score), peripheral edema, pruritus, and palmar erythema. As observed, despite having stopped beta\u2010blockers, F1 esophageal varices disappeared (60%), whereas F2 decreased to F1. The Doppler ultrasound aspect of partial (40%) or total (20%) atrophy was either reduced (60%) or reverted to normal (20%), and the respiratory dynamics of the portal vein improved (80%) or normalized (20%), whereas gross scarring nodules disappeared in 40% of cases. These promising data pave the way for an innovative physiopathological approach with extensive clinical applications.<\/jats:p>","DOI":"10.1196\/annals.1297.107","type":"journal-article","created":{"date-parts":[[2004,7,10]],"date-time":"2004-07-10T21:39:14Z","timestamp":1089495554000},"page":"572-576","source":"Crossref","is-referenced-by-count":4,"title":["Cirrhosis Progression as a Model of Accelerated Senescence: Affecting the Biological Aging Clock by a Breakthrough Biophysical Methodology"],"prefix":"10.1111","volume":"1019","author":[{"given":"G","family":"MARINEO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"MAROTTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"SISTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01413.x"},{"key":"e_1_2_5_3_2","unstructured":"Marineo G. 1995. Application of thermodynamics in treatment of unaestheticism. V World Congress of International Society of Dermatology. October 26\u201029 1995. Montecatini Italy."},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","unstructured":"Marineo G. E. Indrizzi G. Gasparini et al.2002. Biophysics\u2010induced tissue regeneration. A pilot study using \u201cDelta\u2010S\u201d Entropy Variation System on Burns Sequelae and Keloids. 19th Kumamoto Medical Bioscience Symp. on Cellular Molecular and Genetic Aspects of Biological Response to Planned and Unplanned Injury. Kumamoto Japan. (This work was awarded the Outstanding Paper Prize.)","DOI":"10.1016\/S0531-5131(03)00660-5"},{"key":"e_1_2_5_5_2","unstructured":"Marineo G. & F. Marotta. 2002. Physiological aging process and functional reserve. Preliminary study with an experimental biophysical anti\u2010aging treatment. 1st Asia Pacific Conf. on Anti\u2010Ageing Medicine. Singapore."},{"key":"e_1_2_5_6_2","unstructured":"Marineo G. & F. Marotta. 2002. Biophysics and aging of immune system. A pilot study on functional recovery of immunodeficiency due to aging and chronic activation\u2010induced stress. 1st Asia Pacific Conf. on Anti Ageing Medicine. Singapore."},{"key":"e_1_2_5_7_2","unstructured":"Marineo G. & F. Marotta. 2003. An innovative biophysical approach to aging of immune system. A pilot study on functional recovery of secondary immunodeficiency. 4th Annual Conf. on Regenerative Medicine. Washington DC."},{"key":"e_1_2_5_8_2","unstructured":"Marineo G. & F. Marotta. 2003. Physiological aging process and functional reserve. Preliminary study with a non\u2010invasive biophysical anti\u2010aging approach. Anti\u2010Aging World Conf. Paris France."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1297.107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1297.107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T21:07:13Z","timestamp":1696799233000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1297.107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1196\/annals.1297.107"],"URL":"https:\/\/doi.org\/10.1196\/annals.1297.107","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}