{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:10:48Z","timestamp":1770675048710,"version":"3.49.0"},"reference-count":4,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T00:00:00Z","timestamp":1138060800000},"content-version":"vor","delay-in-days":785,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> During apoptosis, an increase in cytosolic Ca<jats:sup>2+<\/jats:sup> concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub>) accompanies the depletion of endoplasmic reticulum (ER). The actual roles of each of the two events in apoptosis are difficult to understand. In this work, we have modulated the basal [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub> and the thapsigargin (THG)\u2010dependent reticular flux (i.e., by chelating extracellular Ca<jats:sup>2+<\/jats:sup> or by modulating intracellular Ca<jats:sup>2+<\/jats:sup> by 3\u2010aminobenzamide [3\u2010ABA]). We have found that these treatments alter these Ca<jats:sup>2+<\/jats:sup> parameters in a differential way and, accordingly, affect apoptosis differentially. We have found that the increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub> is related to the extent of apoptosis, whereas the ER depletion affects the apoptotic nuclear morphology by shifting it towards the cleavage mode.<\/jats:p>","DOI":"10.1196\/annals.1299.011","type":"journal-article","created":{"date-parts":[[2004,3,22]],"date-time":"2004-03-22T19:28:16Z","timestamp":1079983696000},"page":"74-77","source":"Crossref","is-referenced-by-count":18,"title":["Cytosolic and Endoplasmic Reticulum Ca<sup>2+<\/sup> Concentrations Determine the Extent and the Morphological Type of Apoptosis, Respectively"],"prefix":"10.1111","volume":"1010","author":[{"given":"CLAUDIA","family":"CERELLA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIA","family":"D'ALESSIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MILENA","family":"DE NICOLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANDREA","family":"MAGRINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANTONIO","family":"BERGAMASCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LINA","family":"GHIBELLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.1.95"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6569"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1156"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83641-4"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1299.011","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1299.011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T20:37:01Z","timestamp":1695674221000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1299.011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1196\/annals.1299.011"],"URL":"https:\/\/doi.org\/10.1196\/annals.1299.011","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}