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By its broad definition, tissue engineering involves the construction of tissue equivalents from donor cells seeded within three\u2010dimensional polymeric scaffolds, then culturing and implanting of the cell\u2010seeded scaffolds to induce and direct the growth of new, healthy tissue. Here, we present an up\u2010to\u2010date summary of research studies in cardiac tissue engineering, with an emphasis on the critical design principles.<\/jats:p>","DOI":"10.1196\/annals.1302.026","type":"journal-article","created":{"date-parts":[[2004,6,16]],"date-time":"2004-06-16T22:38:16Z","timestamp":1087425496000},"page":"312-319","source":"Crossref","is-referenced-by-count":63,"title":["Myocardial Tissue Engineering: Creating a Muscle Patch for a Wounded Heart"],"prefix":"10.1111","volume":"1015","author":[{"given":"JONATHAN","family":"LEOR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SMADAR","family":"COHEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"issue":"1","key":"e_1_2_8_2_2","first-page":"S132","article-title":"Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation","volume":"354","author":"Vacanti J.P.","year":"1999","journal-title":"Lancet"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/421884a"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024725818835"},{"key":"e_1_2_8_5_2","first-page":"201","article-title":"Cardiomyocyte transplantation into the failing heart\u2014new therapeutic approach for heart failure? 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