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The mathematical sensorimotor feedforward model of otolith control of three\u2010dimensional binocular eye position is based on relevant anatomical connections of the vestibuloocular reflex from the utricles to extraocular eye muscles. This is the first attempt to simulate static ocular motor syndromes for unilateral utricular or vestibular nerve failure, lesions of the vestibular nucleus, and lesions of the ascending vestibuloocular reflex pathways. Comparison of the predicted syndromes with those found in patients with unilateral disorders of the vestibular nerve (herpes zoster neuritis), the vestibular nucleus (medullary infarction), and the medial longitudinal fasciculus (pontine infarction) showed good agreement as regards the direction of horizontal, vertical, and torsional eye deviations. The ability of the model to simulate complete or incomplete failures of single elements or entire pathways allows us to pose direct clinical questions about as yet unknown ocular motor syndromes or about the localization of the damage as well as the mechanism involved in syndromes already known.<\/jats:p>","DOI":"10.1196\/annals.1303.013","type":"journal-article","created":{"date-parts":[[2004,1,15]],"date-time":"2004-01-15T01:04:15Z","timestamp":1074128655000},"page":"142-157","source":"Crossref","is-referenced-by-count":3,"title":["Mathematical Model Predicts Clinical Ocular Motor Syndromes"],"prefix":"10.1111","volume":"1004","author":[{"given":"MARIANNE","family":"DIETERICH","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEFAN","family":"GLASAUER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"THOMAS","family":"BRANDT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235644"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237157"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00335351"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00332912"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/20441"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.5.2295"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330518"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330311"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199812010-00014"},{"key":"e_1_2_6_11_2","unstructured":"Olszewski J. & D. 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