{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:06:52Z","timestamp":1780067212133,"version":"3.54.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T00:00:00Z","timestamp":1138060800000},"content-version":"vor","delay-in-days":785,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Agmatine is a polycationic amine synthesized from L\u2010arginine by arginine decarboxylase in brain and several tissues. It binds to N\u2010methyl\u2010D\u2010aspartate (NMDA) subtype of glutamatergic, a<jats:sub>2<\/jats:sub>\u2010adrenergic and imidazoline (I) receptors. The present study was designed to investigate effect of agmatine on acute and mononeuropathic pain after chronic constriction injury (CCI). CCI was created by four loose ligations around the right sciatic nerve. The analgesic threshold in rats was evaluated by using thermal hyperalgesia\/allodynia (THA) at 4\u00b0C. The evaluations were made preoperatively, on postoperative day 15, and after drug administration. Agmatine (10, 20, 40, 80, and 100 mg\/kg) was administered intraperitoneally for 5 days beginning on postoperative day 15. Agmatine significantly reduced the hyperalgesia in all doses applied. When agmatine was injected intraperitoneally (10, 20, 40, 80, and 100 mg\/kg), it increased the nociceptive threshold in the tail\u2010immersion test in a dose\u2010dependent manner, but it had no effect in the hot\u2010plate test. This effect of agmatine in the tail\u2010immersion test was blocked by both yohimbine (1 mg\/kg) and idazoxan (0.5 mg\/kg). When agmatine was administered intracerebroventricularly (25\u2010200 mg\/10 mL), it increased the nociceptive threshold in the hot\u2010plate but not in the tail\u2010immersion test. We conclude that agmatine, an endogenous substance derived from arginine, can modulate both acute and chronic pain.<\/jats:p>","DOI":"10.1196\/annals.1304.010","type":"journal-article","created":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T23:23:23Z","timestamp":1079565803000},"page":"106-115","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Agmatine on Acute and Mononeuropathic Pain"],"prefix":"10.1111","volume":"1009","author":[{"given":"FEYZA","family":"ARICIOGLU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EYLEM","family":"KORCEGEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AYHAN","family":"BOZKURT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SULEYMAN","family":"OZYALCIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90270-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(92)90112-J"},{"key":"e_1_2_5_4_2","first-page":"8","article-title":"Pharmacological characterization of imidazoline receptor proteins identified by immunological techniques and other methods","volume":"881","author":"Pablo V.E.","year":"1998","journal-title":"Ann. 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