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We show that a subset of CD8<jats:sup>+<\/jats:sup> T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member (gp180) and CD1d. This subset, which is regulatory <jats:italic>in vitro<\/jats:italic>, may play a role in the control of intestinal immune responses toward luminal antigens. A lack of expansion of these CD8<jats:sup>+<\/jats:sup> regulatory T cells, probably related to the defective expression of the gp180\/CD1d complex, is observed in inflammatory bowel disease.<\/jats:p>","DOI":"10.1196\/annals.1309.004","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T07:17:40Z","timestamp":1106896660000},"page":"22-35","source":"Crossref","is-referenced-by-count":30,"title":["Activation of a Unique Population of CD8<sup>+<\/sup> T Cells by Intestinal Epithelial Cells"],"prefix":"10.1111","volume":"1029","author":[{"given":"MATTHIEU","family":"ALLEZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JENS","family":"BRIMNES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LING","family":"SHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IRIS","family":"DOTAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ATSUSHI","family":"NAKAZAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LLOYD","family":"MAYER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.4049\/jimmunol.151.12.7307","article-title":"Epitopes of myelin basic protein that trigger TGF\u2010beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope\u2010driven bystander suppression","volume":"151","author":"Miller A.","year":"1993","journal-title":"J. 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