{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:42:45Z","timestamp":1784133765177,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T00:00:00Z","timestamp":1137542400000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> According to international criteria, autoimmune hepatitis (AIH) type 1 is characterized by the presence of antinuclear or anti\u2010smooth muscle antibodies (SMA) with F\u2010actin specificity. SMA have been found in 85% of AIH patients, but are not specific to this disease, and anti\u2010F\u2010actin specificity is not always verified when SMA are detected. The objective of this study was to determine the diagnostic value of anti\u2010F\u2010actin antibodies in a large population. A multicenter study involving 12 clinical centers was performed. Patients were selected on the basis of the presence of F\u2010actin SMA detected by indirect immunofluorescence (IIF) on rat liver\u2010kidney\u2010stomach sections and was confirmed by IIF on Hep2 cells treated with colchicine, or F\u2010actin dot\u2010blot. The clinical status of patients was determined from their medical records. One hundred sixty\u2010eight patients were included: 76% women, 24% men; mean age of 45 years (range, 2\u201388 years), with a bimodal age distribution. Sixty percent had AIH type 1, and 40% had another disease. In the group of women younger than 25 years, 90% had AIH type 1. Other pathologies associated with antiactin were other liver diseases (19%), including viral hepatitis C (7%), and nonliver diseases (21%), including connective tissue diseases (12%). Antibody titers were higher in AIH than in other diseases. Antiactin antibodies are of major diagnostic value in AIH, especially in young women; they may be found in other disease settings, but mostly at low levels.<\/jats:p>","DOI":"10.1196\/annals.1313.028","type":"journal-article","created":{"date-parts":[[2005,7,12]],"date-time":"2005-07-12T19:14:25Z","timestamp":1121195665000},"page":"266-273","source":"Crossref","is-referenced-by-count":43,"title":["Diagnostic Value of Anti\u2010F\u2010Actin Antibodies in a French Multicenter Study"],"prefix":"10.1111","volume":"1050","author":[{"given":"P","family":"CHRETIEN\u2010LEPRINCE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"BALLOT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"ANDRE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N O","family":"OLSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"FABIEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"ESCANDE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"OKSMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"DUBUQUOI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"JEGO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"GOETZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"CHEVAILLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"SANMARCO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R L","family":"HUMBEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"JOHANET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)92505-5"},{"key":"e_1_2_6_3_2","first-page":"473","article-title":"Human smooth muscle autoantibody: its identification as antiactin antibody and a study of its binding to nonmuscular cells","volume":"72","author":"Gabbiani G.","year":"1973","journal-title":"Am. 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G.","year":"1976","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_6_15_2","unstructured":"Abuaf N. C. Johanet & J.C. Homberg. 1991. Autoantibodies in autoimmune chronic active hepatitis.InAutoimmune Liver Diseases pp. 93\u2013109. Raven Press. New York."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02166-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80361-X"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.08.002"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.29.5.403"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230525"},{"key":"e_1_2_6_21_2","first-page":"261","article-title":"Anti\u2010actin antibodies in acute viral hepatitis A in children","volume":"28","author":"Lopez S.I.","year":"1998","journal-title":"Acta Gastroenterol. 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