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However, there may be other stress\u2010related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1\u2010year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.<\/jats:p>","DOI":"10.1196\/annals.1314.002","type":"journal-article","created":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T23:49:08Z","timestamp":1106783348000},"page":"8-13","source":"Crossref","is-referenced-by-count":49,"title":["Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups"],"prefix":"10.1111","volume":"1032","author":[{"given":"J","family":"HELLHAMMER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"SCHLOTZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A A","family":"STONE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"PIRKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"HELLHAMMER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_4_2_2","unstructured":"Schmidt I. 2003. 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