{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:45:39Z","timestamp":1791006339676,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":407,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Research has shown that exposure to repeated stress alters acute behavioral and neurochemical responses to drugs of abuse. However, few studies have characterized the longer\u2010term detrimental effects of psychostimulant drugs such as methamphetamine (METH) after exposure to chronic stress. The current study tested whether 10 days of unpredictable stress produced greater striatal dopamine depletions after neurotoxic injections of METH and whether monoamine reuptake blockers protected against stress\/METH\u2010induced DA depletion. Male rats were exposed to 10 d of unpredictable stress or weighed daily but not stressed. On day 11, all rats were given 4 injections of 0, 7.5, or 10 mg\/kg METH, 1 injection every 2 h, and tissue collected 7 d later. Male rats exposed to unpredictable stress had greater depletions of striatal dopamine tissue content than nonstressed controls injected with METH. In a separate study, rats were treated with vehicle, desipramine (10 mg\/kg), or fluoxetine (5 mg\/kg) daily during the 10\u2010d stress regimen. These antidepressants did not attenuate the stress\u2010potentiated depletion of striatal dopamine. These findings suggest that chronic unpredictable stress enhances vulnerability of the brain to neurotoxic effects of psychostimulants, but this vulnerability is mediated through mechanisms other than the norepinephrine or serotonin uptake systems.<\/jats:p>","DOI":"10.1196\/annals.1314.049","type":"journal-article","created":{"date-parts":[[2005,1,26]],"date-time":"2005-01-26T23:49:08Z","timestamp":1106783348000},"page":"312-314","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Chronic Stress on Methamphetamine\u2010Induced Dopamine Depletions in the Striatum"],"prefix":"10.1111","volume":"1032","author":[{"given":"LESLIE","family":"MATUSZEWICH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRYAN K.","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890170310"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.3.377"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244853"},{"key":"e_1_2_5_5_2","first-page":"89","article-title":"Effect of imipramine on brain D\u20101 and 5\u2010HT\u20102A receptors in a chronic unpredictable stress model in rats","volume":"54","author":"Ossowska G.","year":"2002","journal-title":"Polish J. Pharmacol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.12.007"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1314.049","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1314.049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T14:39:37Z","timestamp":1695652777000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1314.049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1196\/annals.1314.049"],"URL":"https:\/\/doi.org\/10.1196\/annals.1314.049","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}