{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:34:13Z","timestamp":1791297253140,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T00:00:00Z","timestamp":1154476800000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold><jats:bold>Septic shock is a systemic response to severe bacterial infections, generally caused by Gram\u2010negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi\u2010organ failure. All these effects, are induced by the generation of pro\u2010inflammatory and vasodilator mediators, cell adhesion molecules, coagulation factors, and acute\u2010phase proteins. Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase\u2010activating polypeptide (PACAP) are two immunopeptides with anti\u2010inflammatory properties exerted through type 1 and 2 VIP receptors (VPAC1 and VPAC2, respectively), and PACAP receptor (PAC1). The present results recapitulate the protective role of PAC1 in an experimental model of lethal endotoxemia using a knockout for the PAC1 receptor. Our results demonstrate that VIP and PACAP decrease lipopolysaccharide (LPS)\u2010induced interleukin\u20106 (IL\u20106) production, neutrophil infiltration and intercellular adhesion molecule\u20101 (ICAM\u20101), vascular cell adhesion molecule\u20101 (VCAM\u20101), and fibrinogen expression through PAC1 receptor, providing an advantage to design more specific drugs complementing standard intensive care therapy in septic shock.<\/jats:bold><\/jats:p>","DOI":"10.1196\/annals.1317.053","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T20:03:11Z","timestamp":1154635391000},"page":"405-410","source":"Crossref","is-referenced-by-count":19,"title":["PAC1 Receptor"],"prefix":"10.1111","volume":"1070","author":[{"given":"CARMEN","family":"MART\u00cdNEZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALICIA","family":"ARRANZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YASMINA","family":"JUARRANZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CATALINA","family":"ABAD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAR\u00cdA","family":"GARC\u00cdA\u2010G\u00d3MEZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FLORENCIA","family":"ROSIGNOLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAVIER","family":"LECETA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSA P.","family":"GOMARIZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319523"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0031-6997(24)01449-2","article-title":"Pituitary adenylate cyclase\u2010activating polypeptide and its receptors: from structure to function","volume":"52","author":"Vaudry D.","year":"2000","journal-title":"Pharmacol. 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