{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:42:04Z","timestamp":1777905724863,"version":"3.51.4"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":407,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Genetic instability is an important facet of carcinogenesis and oncogenesis, generating chromosomal variability and extensive intratumor heterogeneity. Common fragile sites are predetermined chromosomal breakage regions. Experimentally, they can be demonstrated as site\u2010specific gaps or breaks seen on metaphase chromosomes under conditions of replicative stress. They have been known for many years as a chromosomal expression of genetic instability and have been implicated to have a causative role in cancer. However, common fragile sites still remain enigmatic intrinsic parts of human chromosomes, and the DNA sequences at most of the fragile sites have noot been identified so far. The idea of genetically tagging fragile site DNA by insertional mutagenesis through an exogenous marker gene has provided a platform for the efficient targeted cloning of a substantial number of common fragile sites.<\/jats:p>","DOI":"10.1196\/annals.1322.002","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T20:08:46Z","timestamp":1105646926000},"page":"14-27","source":"Crossref","is-referenced-by-count":44,"title":["Common Fragile Sites and Cancer: Targeted Cloning by Insertional Mutagenesis"],"prefix":"10.1111","volume":"1028","author":[{"given":"ISABEL","family":"B\u00dcTTEL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANNE","family":"FECHTER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MANFRED","family":"SCHWAB","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"740","article-title":"Persisting clone of cells with an abnormal chromosome in a woman previously irradiated","volume":"6","author":"Dekaban A.","year":"1965","journal-title":"J. Nucl. Med"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.877551"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90144-1"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320550202"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90092-0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00209017"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00504-9"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(91)90013-S"},{"key":"e_1_2_8_10_2","first-page":"123","article-title":"Spontaneous expression of the chromosome fragile site fra(10)(q25)","volume":"35","author":"Taylor A.M.","year":"1983","journal-title":"Am. J. Hum. Genet"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90042-8"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2280(1997)29:3<250::AID-EM4>3.0.CO;2-G"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/1050-3862(91)90056-W"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02267080"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010276"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050713"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274145"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(98)01628-X"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000132181"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-46870-4_11"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(95)80046-8"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00272988"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(95)90011-X"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.32.1.7"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/35106058"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206171"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.20.7143-7151.2003"},{"key":"e_1_2_8_28_2","first-page":"59","article-title":"Fragile sites are targets of diverse mutagens and carcinogens","volume":"1","author":"Yunis J.J.","year":"1987","journal-title":"Oncogene"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014261909613"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00272384"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10047"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284105"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6239375"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00388461"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091095898"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90381-X"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.4.755"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.3.431"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.12.4420-4427.2000"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8141"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7456"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205573"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.11.1651"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01113-3"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.842500"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.1.159"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00855-1"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00158-1"},{"key":"e_1_2_8_49_2","first-page":"265","article-title":"Chromosome breakage and recombination at fragile sites","volume":"43","author":"Glover T.W.","year":"1988","journal-title":"Am. J. Hum. Genet"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(96)00216-6"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.10068"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200009)22:6<591::AID-HED8>3.0.CO;2-C"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(95)00077-1"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90070-2"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1951.016.01.004"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00472-4"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05332.x"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80201-9"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.8.5202"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090013497"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00017-X"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.23.2887"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90054-4"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90084-8"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195804"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206170"},{"key":"e_1_2_8_67_2","first-page":"5916","article-title":"Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites","volume":"60","author":"Thorland E.C.","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207006"},{"key":"e_1_2_8_69_2","first-page":"805","article-title":"Sites of recombinant adeno\u2010associated virus integration","volume":"12","author":"Rivadeneira E. D.","year":"1998","journal-title":"Int. J. Oncol"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(03)00007-7"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0329"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6657"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1390"},{"key":"e_1_2_8_74_2","first-page":"1166","volume":"57","author":"Zimonjic D. B.","year":"1997","journal-title":"Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene. Cancer Res"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14584"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1200202"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203488"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6321"},{"key":"e_1_2_8_79_2","first-page":"1683","article-title":"Chromosomal fragile site FRA16D and DNA instability in cancer","volume":"60","author":"Mangelsdorf M.","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10000"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(02)00029-0"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1322.002","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1322.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T17:26:16Z","timestamp":1695662776000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1322.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1196\/annals.1322.002"],"URL":"https:\/\/doi.org\/10.1196\/annals.1322.002","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}