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Interaction among the elements of the metabolic syndrome\/insulin resistance (MS\/IR) in atherogenesis is currently the subject of much research. Efforts to understand the elements of the dyslipidemias associated with MS\/IR are now beginning to pay off. An increasing number of drugs and other interventions have been shown to be effective in clinical trials in reducing risk factors and improving outcomes. The advantages and disadvantages of possible treatments of these dyslipidemias, including the risks and benefits of combination therapy, are discussed in detail. Finally, strategies for maintaining glucose control and the role of inflammation associated with MS\/IR and CVD are described.<\/jats:p>","DOI":"10.1196\/annals.1323.024","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T01:54:09Z","timestamp":1135907649000},"page":"159-178","source":"Crossref","is-referenced-by-count":4,"title":["Controversies in Dyslipidemias: Atheroprevention in Diabetes and Insulin Resistance"],"prefix":"10.1111","volume":"1055","author":[{"given":"ELIOT A.","family":"BRINTON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,22]]},"reference":[{"key":"e_1_2_10_2_2","first-page":"434","article-title":"Diabetes, other risk factors, and 12\u2010yr cardiovascular mortality for men screened in the Multiple","volume":"16","author":"Stamler J.","year":"1993","journal-title":"Risk Factor Intervention Trial."},{"key":"e_1_2_10_3_2","first-page":"303","article-title":"The Bedford Study: observations on retina and lens of subjects with impaired glucose tolerance and in controls with normal glucose tolerance","volume":"9","author":"McCartney P.","year":"1983","journal-title":"Diabetes Metab."},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390404"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09327-3"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050461"},{"key":"e_1_2_10_9_2","first-page":"195","article-title":"A pilot study with simvastatin and folic acid\/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH)","volume":"10","author":"McMahon M.","year":"2000","journal-title":"Nutr. 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