{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:40:12Z","timestamp":1783474812710,"version":"3.55.0"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> We conducted a two\u2010year follow\u2010up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17\/40) remained significantly (<jats:styled-content><jats:italic>p<\/jats:italic> &lt; .001<\/jats:styled-content>) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.<\/jats:p>","DOI":"10.1196\/annals.1325.058","type":"journal-article","created":{"date-parts":[[2005,4,12]],"date-time":"2005-04-12T11:02:19Z","timestamp":1113303739000},"page":"521-523","source":"Crossref","is-referenced-by-count":47,"title":["Abnormal Eye Movements Predict Disability in MS: Two\u2010Year Follow\u2010Up"],"prefix":"10.1111","volume":"1039","author":[{"given":"JOY","family":"DERWENSKUS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JANET C.","family":"RUCKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALESSANDRO","family":"SERRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHN S.","family":"STAHL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DEBORAH L.","family":"DOWNEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NANCY L.","family":"ADAMS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.JOHN","family":"LEIGH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_3_2_2","first-page":"139","article-title":"A longitudinal study of brain atrophy in relapsing multiple sclerosis","volume":"53","author":"Simon J.H.","year":"1999","journal-title":"The Multiple Sclerosis Collaborative Research Group (MSCRG). Neurology"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02849.x"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-1038-8"},{"key":"e_1_2_3_5_2","unstructured":"Leigh R.J. & D.S. Zee. 1999. The Neurology of Eye Movements 3rd ed. Oxford University Press. New York."},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.2.291"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.2.291"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1325.058","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1325.058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T07:38:05Z","timestamp":1695627485000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1325.058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1196\/annals.1325.058"],"URL":"https:\/\/doi.org\/10.1196\/annals.1325.058","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}