{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:42:24Z","timestamp":1790905344730,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:00:00Z","timestamp":1156377600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>\n            <jats:italic>Shigella<\/jats:italic>, a Gram\u2010negative bacterial species of the family Enterobacteriaceae, causes bacillary dysentery in humans, an acute rectocolitis that reflects the capacity of the microorganism to disrupt, invade, and cause the inflammatory destruction of the intestinal epithelium. Here, the pathogenesis of <jats:italic>Shigella<\/jats:italic> infection is analyzed in the context of the disruption of the homeostatic balance that protects the gut against inflammation in the presence of its commensal flora. Thus a unified view by which enteroinvasive pathogens allow identification of key signalling molecules and pathways involved in the regulation of intestinal inflammation, thereby providing keys to understand inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1326.025","type":"journal-article","created":{"date-parts":[[2006,10,21]],"date-time":"2006-10-21T00:36:02Z","timestamp":1161390962000},"page":"307-312","source":"Crossref","is-referenced-by-count":33,"title":["The Bacterial Weaponry"],"prefix":"10.1111","volume":"1072","author":[{"given":"PHILIPPE J.","family":"SANSONETTI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119522"},{"key":"e_1_2_5_3_2","first-page":"306","article-title":"Structure and function of the intestinal epithelial barrier in health and disease","volume":"31","author":"Madara J.L.","year":"1990","journal-title":"Monogr. Pathol."},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1499"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104816"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106442"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2001.tb00569.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090124"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/35079107"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/35079114"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00244"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/iai.35.3.852-860.1982","article-title":"Involvement of a large plasmid in the invasive ability of Shigella flexneri","volume":"35","author":"Sansonetti P.J.","year":"1982","journal-title":"Infect. Immun."},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.3.683"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.12.3249"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200402073"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3867"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.146.6.1319"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90358-1"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1021"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"33878","DOI":"10.1074\/jbc.M303749200","article-title":"The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco\u20102","volume":"278","author":"P\u00e9dron T.","journal-title":"J. Biol. Chem."},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.903"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/417091a"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1471-1480.1999"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1591"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve155"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni945"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084677"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200651200"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1131"},{"key":"e_1_2_5_30_2","first-page":"14046","article-title":"The Shigella flexneri","volume":"102","author":"Kim D.W.","year":"2006","journal-title":"of effector OspG interfere with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc. NatL. Acad. Sci. USA"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1326.025","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1326.025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:06:24Z","timestamp":1695611184000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1326.025"}},"subtitle":["Lessons from <i>Shigella<\/i>"],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1196\/annals.1326.025"],"URL":"https:\/\/doi.org\/10.1196\/annals.1326.025","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}