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Parathyroid hormone (PTH) is an 84\u2010amino\u2010acid peptide, synthesized and released by parathyroid chief cells in response to hypocalcemia. PTH mobilizes calcium by increasing calcium resorption from bone and by raising calcium reabsorption in the proximal kidney tubule. Treatment with active vitamin D can increase vitamin D receptor expression, inhibit growth of parathyroid tumors, and reduce PTH levels in patients with hyperparathyroidism (HPT). Newly developed vitamin D analogues with reduced calcemic effects and with more pronounced antiproliferative effect may provide new favorable treatment for reversal of HPT.<\/jats:p>","DOI":"10.1196\/annals.1327.005","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:38:18Z","timestamp":1115930298000},"page":"53-58","source":"Crossref","is-referenced-by-count":35,"title":["Parathyroid Glands in Calcium Regulation and Human Disease"],"prefix":"10.1111","volume":"1040","author":[{"given":"G\u00d6RAN","family":"\u00c5KERSTR\u00d6M","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PER","family":"HELLMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLA","family":"HESSMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ULRIKA","family":"SEGERSTEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GUNNAR","family":"WESTIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Johansson H. 1994. 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