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Extensive research in the last few years has shown that the pathway that activates this transcription factor can be interrupted by phytochemicals derived from spices such as turmeric (curcumin), red pepper (capsaicin), cloves (eugenol), ginger (gingerol), cumin, anise, and fennel (anethol), basil and rosemary (ursolic acid), garlic (diallyl sulfide, <jats:italic>S<\/jats:italic>\u2010allylmercaptocysteine, ajoene), and pomegranate (ellagic acid). For the first time, therefore, research provides \u201creasoning for seasoning.\u201d<\/jats:p>","DOI":"10.1196\/annals.1329.054","type":"journal-article","created":{"date-parts":[[2005,1,19]],"date-time":"2005-01-19T23:57:53Z","timestamp":1106179073000},"page":"434-441","source":"Crossref","is-referenced-by-count":273,"title":["Suppression of the Nuclear Factor\u2010\u03baB Activation Pathway by Spice\u2010Derived Phytochemicals: Reasoning for Seasoning"],"prefix":"10.1111","volume":"1030","author":[{"given":"BHARAT B.","family":"AGGARWAL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHISHIR","family":"SHISHODIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402482"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0555-y"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-7847-1_8"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-579X(02)00128-1"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02375-4"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01377-8"},{"key":"e_1_2_11_8_2","first-page":"229","article-title":"NF\u2010\u03baB as an integrator of diverse signaling pathways: the heart of myocardial signaling? 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