{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:02:32Z","timestamp":1791018152125,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":407,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Endometriosis is an important gynecological disease, pathologically defined by the ectopic presence of both endometrial glands and stroma, and clinically associated with pelvic pain and infertility. Our current knowledge of the pathogenesis, pathophysiology of related infertility, and spontaneous evolution is still limited, although endometriosis has been described for many years. Future research in endometriosis needs to focus on pathogenesis studies in the baboon model and on the early interactions between endometrial and peritoneal cells in the pelvic cavity at the time of menstruation. Proteomic and genomic approaches are needed to detect potential differences between eutopic endometrium and myometrium in women with and without endometriosis. Immunomodulatory drugs inhibiting endometriosis\u2010associated pelvic inflammation may offer new medical treatment for endometriosis in the future.<\/jats:p>","DOI":"10.1196\/annals.1335.034","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T17:01:10Z","timestamp":1109264470000},"page":"316-325","source":"Crossref","is-referenced-by-count":29,"title":["Future Directions in Endometriosis Research"],"prefix":"10.1111","volume":"1034","author":[{"given":"THOMAS M.","family":"D'HOOGHE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"KYAMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"DEBROCK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"MEULEMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JASON M.","family":"MWENDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,12]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81391-X"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.1.84"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41317"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(02)00051-7"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30003-X"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.1802"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.4.605"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod66.1.1"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01699-X"},{"key":"e_1_2_9_11_2","first-page":"780","article-title":"Endometrial induction of endometriosis across millipore filters","volume":"94","author":"Merrill J.A.","year":"1966","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55976-7"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(99)01497-5"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00114-1"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111715"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1230217"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00379-4"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.426"},{"key":"e_1_2_9_19_2","first-page":"O\u20102","article-title":"Recombinant human TNF binding protein (r\u2010hTBP\u20101) inhibits the development of endometriosis in baboons: a prospective, randomized, placebo\u2010 and drug\u2010controlled study. Presented at the Annual Meeting of the ASRM, Orlando, USA, October 22\u201024, 2001","volume":"76","author":"D'Hooghe T.M.","year":"2001","journal-title":"Fertil. Steril."},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.09.034"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119478"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021912"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02955-7"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03325-3"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41318"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0043"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg019"},{"key":"e_1_2_9_28_2","first-page":"551","article-title":"Genomic\u2010wide cDNA microarray analysis of gene\u2010expression profiles involved in ovarian endometriosis","volume":"22","author":"Arimoto T.","year":"2003","journal-title":"Int. J. Oncol."},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03317-4"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03322-8"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg300"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8885"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03329-0"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(02)00063-3"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)48988-0"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90136-5"},{"key":"e_1_2_9_37_2","unstructured":"Isahakia M.A. & C.S. Bambra. 1990. Primate models for research in reproduction.InGamete Interaction: Prospects for Immunocontraception. :487\u2010500. Wiley\u2010Liss. New York."},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)60429-6"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90180-9"},{"key":"e_1_2_9_40_2","first-page":"23","article-title":"Ovarian stimulation, egg aspiration, In vitro fertilization, and embryo transfer in the baboon (Papio anubis): a pilot project at the Institute of Primate Research, Nariobi, Kenya","volume":"57","author":"D'Hooghe T.M.","year":"2004","journal-title":"Gynecol. Obstet. Invest."},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00277-X"},{"key":"e_1_2_9_42_2","first-page":"217","article-title":"Endometriosis in a baboon","volume":"28","author":"Folse D.S.","year":"1978","journal-title":"Lab. Anim. Sci."},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58641-5"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00406-9"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2345(200101)53:1<47::AID-AJP4>3.0.CO;2-X"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004040000126"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00982-8"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6567.272"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.294.6580.1117"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91602-7"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53755-8"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm001000c"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.8.1562"},{"key":"e_1_2_9_54_2","first-page":"192","article-title":"Studies on the effect of the new non\u2010steroidal aromatase inhibitor fadrozole hydrochloride in an endometriosis model in rats","volume":"46","author":"Yano S.","year":"1996","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(97)00074-5"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00022-3"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02798.x"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(00)00073-5"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00087-4"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.12.2944"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00157-0"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1335.034","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1335.034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:27:52Z","timestamp":1695623272000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1335.034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1196\/annals.1335.034"],"URL":"https:\/\/doi.org\/10.1196\/annals.1335.034","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}