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Single mutation in each of the three known insulin family receptor tyrosine kinases alone has limited effects on sexual differentiation; however, compound mutations result in formation of ovotestes, and triple mutations cause male\u2010to\u2010female sexual reversal. The implications of our mouse models are discussed.<\/jats:p>","DOI":"10.1196\/annals.1336.002","type":"journal-article","created":{"date-parts":[[2006,2,7]],"date-time":"2006-02-07T23:23:00Z","timestamp":1139354580000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Hormonal Regulation of Male Reproductive Tract Development"],"prefix":"10.1111","volume":"1061","author":[{"given":"SUNITA","family":"VERMA\u2010KURVARI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SERGE","family":"NEF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUIS F.","family":"PARADA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.6.2447"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.843800"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1071\/RD9940151"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.2.259"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2795(199705)47:1<30::AID-MRD5>3.0.CO;2-R"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74364-6"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/10364"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)56240-0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.223"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67085-1"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0830295"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(96)80016-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9785"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00327-5"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1381"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1193-301"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00408-1"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02059"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.6.0452"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092952"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-71"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91970-W"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91820-C"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020957809082"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-106"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00498.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80084-4"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.16.5624-5630.2001"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(03)00265-6"},{"key":"e_1_2_7_31_2","first-page":"365","article-title":"Polycystic ovary syndrome: syndrome XX? 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