{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:32:58Z","timestamp":1758126778309},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T00:00:00Z","timestamp":1136764800000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Somatic cells in the majority of colorectal polyps and cancers contain mutations\/deletions in the adenomatous polyposis coli (APC) tumor suppressor gene. APC is involved in normal intestinal development and acts to influence a variety of cellular processes. Loss of APC function leads to intestinal neoplasia in both mice and humans. APC influences expression of specific genes, including the c\u2010Myc oncogene, which functions as a transcriptional activator. Loss of APC function leads to alterations in c\u2010Myc\u2010regulated genes including ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis. A single nucleotide polymorphism (SNP) in the ODC promoter affecting c\u2010Myc\u2010dependent expression has been associated with risk of colorectal and other cancers. Pharmaceuticals that target structural features of the c\u2010Myc promoter, and suppress expression of c\u2010Myc and other genes regulated by similar promoter elements, are being developed as potential colorectal cancer chemotherapies. Difluoromethylornithine (DFMO), a selective inhibitor of ODC, is under clinical evaluation as a colorectal cancer chemopreventive agent. APC and APC\u2010dependent genes, such as c\u2010Myc and ODC, may be useful as genetic markers of risk and as targets for chemoprevention and therapy for colorectal cancer.<\/jats:p>","DOI":"10.1196\/annals.1339.033","type":"journal-article","created":{"date-parts":[[2005,12,28]],"date-time":"2005-12-28T21:48:19Z","timestamp":1135806499000},"page":"97-105","source":"Crossref","is-referenced-by-count":12,"title":["A Comprehensive Strategy to Combat Colon Cancer Targeting the Adenomatous Polyposis Coli Tumor Suppressor Gene"],"prefix":"10.1111","volume":"1059","author":[{"given":"EUGENE W.","family":"GERNER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NATALIA A.","family":"IGNATENKO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"LANCE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAURENCE H.","family":"HURLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,9]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.1.8"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1521"},{"key":"e_1_2_7_4_2","first-page":"915","article-title":"Recommendations for follow\u2010up care of individuals with an inherited predisposition to cancer","volume":"277","author":"Burke W.","year":"1997","journal-title":"I. 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