{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:48:22Z","timestamp":1761947302141},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T00:00:00Z","timestamp":1136505600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> There has been progress in the application of stem cell transplantation for treatment of an increasing number of severe congenital and acquired bone marrow disorders, currently restricted by the availability of human leukocyte antigen (HLA)\u2010matched related donors. Preimplantation HLA typing has recently been introduced to improve the access to stem cell therapy for inherited bone marrow failures. Preimplantation genetic diagnosis (PGD) provides an option not only for avoiding an affected pregnancy with thalassemia and other inherited disorders but also for preselection of the HLA\u2010compatible donors for affected siblings. Multiple short tandem repeat markers throughout the HLA region are applied for this purpose, allowing 100% accuracy of HLA typing, through picking up possible recombination in the HLA region, as well as the copy number of chromosome 6, which affect accuracy of preimplantation HLA typing. Present experience of preimplantation HLA typing includes preimplantation HLA typing in 180 cycles, 122 of which were done as part of PGD for Fanconi anemia, thalassemia, Wiscott\u2010Aldrich syndrome, hyper\u2010immunoglobulin M syndrome, hypohidrotic ectodermal dysplasia with immune deficiency, and X\u2010linked adrenoleukodystrophy, and 58 for the sole purpose of HLA typing for leukemias and for aplastic and Diamond\u2010Blackfan anemia. The applied method resulted in the accurate preselection and transfer of 100% HLA\u2010matched embryos, yielding already three dozen clinical pregnancies and the birth of two dozen HLA\u2010matched children to the siblings requiring stem cell transplantation. Successful therapy with HLA\u2010matched stem cells, obtained from these PGD children, has been achieved already for Diamond\u2010Blackfan anemia hypohidrotic ectodermal dysplasia with immune deficiency and thalassemia.<\/jats:p>","DOI":"10.1196\/annals.1345.028","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T23:18:51Z","timestamp":1134083931000},"page":"223-227","source":"Crossref","is-referenced-by-count":46,"title":["Preimplantation Genetics: Improving Access to Stem Cell Therapy"],"prefix":"10.1111","volume":"1054","author":[{"given":"ANVER","family":"KULIEV","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SVETLANA","family":"RECHITSKY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ILAN","family":"TUR\u2010KASPA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YURY","family":"VERLINSKY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.24.3130"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh153"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61637-9"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62172-4"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.17.2079"},{"key":"e_1_2_2_7_2","unstructured":"Baker S. & J. Wagner. 2004. Advantages of umbilical cord blood transplantation. Abstracts of International Seminar on Preimplantation HLA Typing and Stem Cell Transplantation. Limassol Cyprus. p. 7\u20108."},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2002.0192"},{"key":"e_1_2_2_9_2","unstructured":"Costeas P.A. 2004. Bone marrow donor registry and availability of HLA\u2010matched donors. Abstracts of International Seminar on Preimplantation HLA Typing and Stem Cell Transplantation. Limassol Cyprus. p. 9."},{"key":"e_1_2_2_10_2","unstructured":"Auerbach A.D. 2004. Preimplantation genetic diagnosis combined with HLA typing: the Fanconi anemia experience as a model. Abstracts of International Seminar on Preimplantation HLA Typing and Stem Cell Transplantation. Limassol Cyprus. p. 13."},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910263211707"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.550601.x"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62133-5"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.17.2125"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60521-4"},{"key":"e_1_2_2_16_2","unstructured":"Marshall J. A. Beaton K. deBoer et al.2004. Preimplantation HLA matching: Sydneys' strategy. Abstracts of International Seminar on Preimplantation HLA Typing and Stem Cell Transplantation. Limassol Cyprus. p. 17."},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60845-0"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1345.028","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1345.028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T20:51:44Z","timestamp":1695675104000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1345.028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1196\/annals.1345.028"],"URL":"https:\/\/doi.org\/10.1196\/annals.1345.028","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}