{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:32:39Z","timestamp":1770823959220,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T00:00:00Z","timestamp":1136505600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> Over the past decades, the incidence of clinically significant transfusion\u2010transmitted diseases has been dramatically reduced. These reductions have occurred because of a multifocal approach to the collection, processing, and release of blood and blood components. Research has focused on characterizing specific pathogens and their infectious patterns, especially the early viremic phase. Donor motivation and characteristics have been investigated, and restrictive eligibility criteria have been established. Regulatory oversight has been strengthened in the United States and hemovigilance systems established in many countries of the European Union, Canada, and Japan to identify new and emerging infectious and noninfectious transfusion risks. Such systems are required because many emerging pathogens will elude the stringent and sensitive donor testing already in place which, unfortunately, requires advanced technologies. Despite the remarkable progress, the processes of delivering a transfusion to a patient provide additional opportunity for risk, but have been less\u2010 well studied and the solutions have been less\u2010well defined. Specific areas of concern include the collection and correct identification of patient samples, selection of modified or unique products, blood administration process, and establishment of specific indications for transfusion. In this chapter, we review the status of transfusion safety in the United States and discuss some emerging infectious and noninfectious risks of transfusion that will become future areas for basic and translational research. The disparities that exist in blood safety in developing countries' red cell alloimmunization and autoimmunity will not be covered.<\/jats:p>","DOI":"10.1196\/annals.1345.040","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T23:18:51Z","timestamp":1134083931000},"page":"325-341","source":"Crossref","is-referenced-by-count":35,"title":["Transfusion Safety: Where Are We Today?"],"prefix":"10.1111","volume":"1054","author":[{"given":"NAOMI L.C.","family":"LUBAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-6892.2004.00441.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41121493.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0042-9007.2004.00410.x"},{"key":"e_1_2_9_5_2","first-page":"495","article-title":"Pathogen reduction technology: methods, status of clinical trials and future prospects","volume":"2","author":"Corash L.","year":"2003","journal-title":"Curr. Hematol. Rep."},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.2.210"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0042-9007.2004.00416.x"},{"key":"e_1_2_9_8_2","unstructured":"Stramer S.L. L. Chambers P.L. Page et al.2003. Third reported US case of breakthrough HIV transmission from NAT screened blood. Transfusion43:40A\u2010S134\u2010040K."},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04215.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00174.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50009"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506013322202"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20030"},{"key":"e_1_2_9_14_2","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood.V95.10.3065","article-title":"Hepatitis C infection among survivors of childhood cancer","volume":"95","author":"Strickland D.K.","year":"2000","journal-title":"Blood"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280534"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199602000-00022"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411202"},{"key":"e_1_2_9_18_2","first-page":"1179","article-title":"Clinical and histological characterization of liver disease in patients with transfusion\u2010dependent beta\u2010thalassemia","volume":"89","author":"Prati D.","year":"2004","journal-title":"A multicenter study of 117 cases. Haematologica"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703133361102"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37697335149.x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703133361101"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010398"},{"key":"e_1_2_9_23_2","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1182\/blood.V90.3.1335","article-title":"Prevalence of hepatitis G virus in patients with aplastic anemia","volume":"90","author":"Kiem H.P.","year":"1997","journal-title":"Blood"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29789369672.x"},{"key":"e_1_2_9_25_2","first-page":"123","article-title":"Epidemiology of transfusion\u2010associated acquired immunodeficiency syndrome in children in the United States, 1981 through 1989","volume":"89","author":"Jones D.S.","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_9_26_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1542\/peds.95.5.717","article-title":"Unrecognized human immunodeficiency virus type 1 infection in a cohort of transfused neonates: a retrospective investigation","volume":"95","author":"Lieb L.E.","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_9_27_2","first-page":"544","article-title":"Seroprevalence of HIV in a transfused pediatric cardiac cohort in a high prevalence area","volume":"33","author":"Wayne C.","year":"1993","journal-title":"Transfusion"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.9.3598.bloodjournal8693598"},{"key":"e_1_2_9_29_2","first-page":"130","article-title":"Parvovirus B19: implications for transfusion medicine","volume":"41","author":"Brown K.E.","year":"2001","journal-title":"Summary of a workshop. Transfusion"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35996029163.x"},{"key":"e_1_2_9_31_2","first-page":"1","volume":"9","author":"UK reports potential case of transfusion\u2010transmitted vCJD.","year":"2003","journal-title":"AABB Weekly Report"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03310.x"},{"key":"e_1_2_9_33_2","unstructured":"Update: Investigations of West Nile Virus Infections in Recipients of Organ Transplantation and Blood Transfusion. 2002. CDC MMWR51: 879."},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03300.x"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.14.1566"},{"key":"e_1_2_9_36_2","first-page":"774","article-title":"The incidence and natural course of transfusion\u2010associated GB virus C\/hepatitis G virus infection in a cohort of thalassemic patients","volume":"91","author":"Prati D.","year":"1998","journal-title":"The Cooleycare Cooperative Group. Blood"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2001.00276.x"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0042-9007.2004.00394.x"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04347.x"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.00646.x"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1345.040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1345.040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T20:55:02Z","timestamp":1695675302000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1345.040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1196\/annals.1345.040"],"URL":"https:\/\/doi.org\/10.1196\/annals.1345.040","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}