{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T19:12:26Z","timestamp":1722366746257},"reference-count":3,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T00:00:00Z","timestamp":1136505600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> In 1989, the Province of Ontario established a molecular diagnostic laboratory for carrier detection and prenatal diagnosis of hemoglobinopathies. Over the past 15 years, the laboratory has provided prenatal diagnosis for 672 pregnancies at\u2010risk for severe hemoglobinopathies: 276 (41%) for homozygous \u03b2\u2010thalassemia or hemoglobin (Hb) E\/\u03b2\u2010thalassemia, 211 (31%) for homozygous \u03b1<jats:sup>0<\/jats:sup>\u2010thalassemia (Hb Bart's hydrops fetalis), and\/or Hb H disease, and 185 (28%) for various sickling disorders (Hb SS, Hb SC, Hb S\/\u03b2\u2010thalassemia). Despite the availability of services for carrier screening, genetic counseling, and prenatal diagnosis, there has been only a modest reduction in the overall incidence of hemoglobinopathies in Ontario.<\/jats:p>","DOI":"10.1196\/annals.1345.052","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T23:18:51Z","timestamp":1134083931000},"page":"507-510","source":"Crossref","is-referenced-by-count":8,"title":["Prenatal Diagnosis of Hemoglobinopathies in Ontario, Canada"],"prefix":"10.1111","volume":"1054","author":[{"given":"RAVEEN K.","family":"BASRAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARGIE","family":"PATTERSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LYNDA","family":"WALKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LISA M.","family":"NAKAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BARRY","family":"ENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID H.K.","family":"CHUI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN S.","family":"WAYE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Canadian Census. 2001.http:\/\/www.statscan.com."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(98)80076-0"},{"key":"e_1_2_5_4_2","first-page":"358","article-title":"Carrier detection and prenatal diagnosis of hemoglobinopathies in Ontario","volume":"16","author":"Waye J.S.","year":"1993","journal-title":"Clin. Investig. Med."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1345.052","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1345.052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T20:52:43Z","timestamp":1695675163000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1345.052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1196\/annals.1345.052"],"URL":"https:\/\/doi.org\/10.1196\/annals.1345.052","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}