{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:25:42Z","timestamp":1791973542239,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T00:00:00Z","timestamp":1136505600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>A<jats:sc>bstract<\/jats:sc>: <\/jats:bold> The pervasiveness of low bone mass (LBM) in \u03b2\u2010thalassemia (Thal) patients (pts) is escalating as the average life expectancy of these pts increases. Adolescence is a period of substantial bone accrual, which is crucial for future bone strength. Studies of LBM are prevalent among adults with Thal. However, limited information exists about bone accrual and LBM in adolescents with the disease. Thirty\u2010one pts with \u03b2\u2010Thal (26 Thal major [TM], 5 Thal intermedia [TI]), aged 9\u201020 years (mean: 15.3 years), 14 males and 17 females, underwent measurement of spinal bone mineral density (BMD) by DEXA (Lunar, Prodigy). Height, weight, body mass index, and Tanner stage were assessed at the time of the BMD measurement. A total of 16.1% of the patients had normal bone mass (<jats:italic>Z<\/jats:italic>\u2265\u22121), 22.6% had reduced bone mass (<jats:italic>Z<\/jats:italic>=\u22121 to \u22122), and 61.3% had low bone mass (<jats:italic>Z<\/jats:italic>\u2264\u22122). BMD <jats:italic>Z<\/jats:italic> correlated with height and weight <jats:italic>Z<\/jats:italic> scores. Some 53.9% of subjects had normal gonadal function and 46.1% had induced puberty with gonadal steroids. BMD <jats:italic>Z<\/jats:italic> significantly worsened with age (<jats:styled-content><jats:italic>P<\/jats:italic> &lt; .0001<\/jats:styled-content>). However, there was no difference in the LBM prevalence between subjects with normal versus those with induced puberty: BMD <jats:italic>Z<\/jats:italic> was \u22122 or less in 71.4% of subjects with normal puberty versus 66.7% in those with induced puberty. Our results indicate a high prevalence of LBM among adolescents with Thal regardless of adequate transfusion and chelation regimens. Bone accrual was found to be suboptimal in adolescents with normal or induced puberty. Thus, calcium and vitamin D supplementation with antiresorptive therapies should be evaluated in the adolescent Thal pt with close monitoring of growth and sexual development.<\/jats:p>","DOI":"10.1196\/annals.1345.063","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T23:18:51Z","timestamp":1134083931000},"page":"462-466","source":"Crossref","is-referenced-by-count":61,"title":["Low Bone Mineral Density in Adolescents with \u03b2\u2010Thalassemia"],"prefix":"10.1111","volume":"1054","author":[{"given":"MARIA G.","family":"VOGIATZI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAREN A.","family":"AUTIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEFFREY E.","family":"MAIT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT","family":"SCHNEIDER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTIN","family":"LESSER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICIA J.","family":"GIARDINA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","unstructured":"Giardina P.J. R. Schneider M. Lesser et al.1995. Abnormal bone metabolism in thalassemia.InEndocrine Disorders in Thalassemia pp. 39\u201046. Springer\u2010Verlag. Berlin\/New York.","DOI":"10.1007\/978-88-470-2183-9_6"},{"key":"e_1_2_6_3_2","first-page":"975","article-title":"High incidence of osteoporosis in thalassemia major","volume":"11","author":"Jensen C.E.","year":"1998","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"e_1_2_6_4_2","unstructured":"Wonke B. C. Jensen J.J. Hanslip et al.1998. Genetic and acquired predisposing factors and treatment of osteoporosis in thalassaemia major. J. Pediatr. Endocrinol. Metab.11(Suppl. 3): 795\u2010801."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.10.1415"},{"key":"e_1_2_6_6_2","first-page":"53","article-title":"Bone strength and the adolescent","volume":"13","author":"Root A.W.","year":"2002","journal-title":"Adolesc. 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