{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:40:52Z","timestamp":1787164852510,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T00:00:00Z","timestamp":1136505600000},"content-version":"vor","delay-in-days":66,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      A\n                      <jats:sc>bstract<\/jats:sc>\n                      :\n                    <\/jats:bold>\n                    Cardiac arrhythmias are among the leading causes of morbidity and mortality of transfusion\u2010dependent, iron\u2010overloaded \u03b2\u2010thalassemia patients. Routine screening with Holter electrocardiogram has been recommended; however, infrequent electrocardiographic changes limit its clinical usefulness. The purpose of this study was to determine the diagnostic yield of Holter electrocardiogram monitoring and its correlation with patient symptoms and disease status. A retrospective analysis was performed on 27 transfusion\u2010dependent thalassemia patients who underwent cardiac questionnaire and Holter screening yearly, in addition to echocardiogram and quantitative iron\u2010level determination. Four patients had clinically significant arrhythmias detected on Holter screening, while 2 patients developed severe cardiac complications secondary to arrhythmias within 1 year of follow\u2010up of normal Holter screening. Early detection of cardiac events among transfusion\u2010dependent thalassemia patients with Holter electrocardiography is not clinically effective. Other screening modalities, including the transtelephonic event recorder, should be evaluated in arrhythmia surveillance.\n                  <\/jats:p>","DOI":"10.1196\/annals.1345.064","type":"journal-article","created":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T18:18:51Z","timestamp":1134065931000},"page":"476-480","source":"Crossref","is-referenced-by-count":16,"title":["Utility of Holter Electrocardiogram in Iron\u2010Overloaded Hemoglobinopathies"],"prefix":"10.1111","volume":"1054","author":[{"given":"NAVEEN","family":"QURESHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KISHOR","family":"AVASARALA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DRUCILLA","family":"FOOTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELLIOTT P.","family":"VICHINSKY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Modell B. & V. Berdoukas. 1984. The Clinical Approach to Thalassemia. Grune & Stratton. New York."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.E0407"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb54070.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90264-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3167"},{"key":"e_1_2_5_7_2","first-page":"233","article-title":"Heart rate variability and ventricular late potentials in \u03b2\u2010thalassemia major","volume":"89","author":"Franzoni F.","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00879-8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205046"},{"key":"e_1_2_5_10_2","first-page":"297","article-title":"Arrhythmia in thalassemia major: evaluation of iron chelating therapy by dynamic ECG","volume":"41","author":"Cavallaro L.","year":"1993","journal-title":"Minerva Cardioangiol."},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-1-53"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-1_Part_1-199601010-00003"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1345.064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1345.064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T16:53:43Z","timestamp":1695660823000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1345.064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1196\/annals.1345.064"],"URL":"https:\/\/doi.org\/10.1196\/annals.1345.064","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}