{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:05:21Z","timestamp":1770411921006,"version":"3.49.0"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold><jats:sc>Abstract:\u2002<\/jats:sc><\/jats:bold>  <jats:bold>We are interested in investigating the function of <jats:italic>Hoxc8<\/jats:italic> in skeletogenesis during mouse development. Previous studies have shown that deregulation of <jats:italic>Hoxc8<\/jats:italic> expression in the mouse leads to several skeletal defects, such as homeotic transformation in the thoracic vertebrae, abnormal development of the rib cage, and overproliferation of chondrocytes in the hypertrophic area.<\/jats:bold>\n          <jats:bold>By deleting a crucial enhancer of <jats:italic>Hoxc8 in vivo<\/jats:italic>, we found that precise temporal expression of <jats:italic>Hoxc8<\/jats:italic> is important for determining the correct identity of the vertebral column in early embryos. We also identified downstream targets of <jats:italic>Hoxc8<\/jats:italic> relevant to osteoblast differentiation at later developmental stages.<\/jats:bold> <\/jats:p>","DOI":"10.1196\/annals.1346.046","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T18:13:44Z","timestamp":1152555224000},"page":"87-94","source":"Crossref","is-referenced-by-count":17,"title":["Multiple Roles of <i>Hoxc8<\/i> in Skeletal Development"],"prefix":"10.1111","volume":"1068","author":[{"given":"ASTER H.","family":"JUAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAIYAN","family":"LEI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PRERNA","family":"BHARGAVA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIELLE","family":"LEBRUN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANK H.","family":"RUDDLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.10.1911"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.9956"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(199809\/10)282:1\/2<196::AID-JEZ22>3.0.CO;2-R"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00672"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006918200"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409700102"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1346.046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1346.046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:41:23Z","timestamp":1695678083000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1346.046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1196\/annals.1346.046"],"URL":"https:\/\/doi.org\/10.1196\/annals.1346.046","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}