{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:45:54Z","timestamp":1787021154250,"version":"build-2736575974"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T00:00:00Z","timestamp":1163721600000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:sc>Abstract:\u2002<\/jats:sc>\n                    <\/jats:bold>\n                    <jats:bold>\n                      Thioaptamers offer advantages over normal phosphate ester backbone aptamers due to their enhanced affinity, specificity, and higher stability, largely due to the properties of the sulfur backbone modifications. Over the past several years,\n                      <jats:italic>in vitro<\/jats:italic>\n                      thioaptamer selection and bead\u2010based thioaptamer selection techniques have been developed in our laboratory. Furthermore, several thioaptamers targeting specific proteins such as transcription factor NF\u2010\u03baB and AP\u20101 proteins have been identified. Selected thioaptamers have been shown diagnostic promise in proteome screens. Moreover, some promising thioaptamers have been shown in preliminary animal therapeutic dosing to increase survival in animal models of infection with West Nile virus.\n                    <\/jats:bold>\n                  <\/jats:p>","DOI":"10.1196\/annals.1348.065","type":"journal-article","created":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T13:28:10Z","timestamp":1165238890000},"page":"116-119","source":"Crossref","is-referenced-by-count":29,"title":["Selection of Thioaptamers for Diagnostics and Therapeutics"],"prefix":"10.1111","volume":"1082","author":[{"given":"XIANBIN","family":"YANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HE","family":"WANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID W. 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