{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:03:27Z","timestamp":1792155807983,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,22]],"date-time":"2006-01-22T00:00:00Z","timestamp":1137888000000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>The use of turmeric, derived from the root of the plant<jats:italic>Curcuma longa<\/jats:italic>, for treatment of different inflammatory diseases has been described in Ayurveda and in traditional Chinese medicine for thousands of years. The active component of turmeric responsible for this activity, curcumin, was identified almost two centuries ago. Modern science has revealed that curcumin mediates its effects by modulation of several important molecular targets, including transcription factors (e.g., NF\u2010\u03baB, AP\u20101, Egr\u20101, \u03b2\u2010catenin, and PPAR\u2010\u03b3), enzymes (e.g., COX2, 5\u2010LOX, iNOS, and hemeoxygenase\u20101), cell cycle proteins (e.g., cyclin D1 and p21), cytokines (e.g., TNF, IL\u20101, IL\u20106, and chemokines), receptors (e.g., EGFR and HER2), and cell surface adhesion molecules. Because it can modulate the expression of these targets, curcumin is now being used to treat cancer, arthritis, diabetes, Crohn's disease, cardiovascular diseases, osteoporosis, Alzheimer's disease, psoriasis, and other pathologies. Interestingly, 6\u2010gingerol, a natural analog of curcumin derived from the root of ginger (<jats:italic>Zingiber officinalis<\/jats:italic>), exhibits a biologic activity profile similar to that of curcumin. The efficacy, pharmacologic safety, and cost effectiveness of curcuminoids prompt us to \u201cget back to our roots\u201d<\/jats:p>","DOI":"10.1196\/annals.1352.010","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T21:37:40Z","timestamp":1135978660000},"page":"206-217","source":"Crossref","is-referenced-by-count":548,"title":["Curcumin: Getting Back to the Roots"],"prefix":"10.1111","volume":"1056","author":[{"given":"SHISHIR","family":"SHISHODIA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GAUTAM","family":"SETHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BHARAT B.","family":"AGGARWAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,22]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"363","article-title":"Anticancer potential of curcumin: preclinical and clinical studies","volume":"23","author":"Aggarwal B.B.","year":"2003","journal-title":"Anticancer Res."},{"key":"e_1_2_8_3_2","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high\u2010risk or pre\u2010malignant lesions","volume":"21","author":"Cheng A.L.","year":"2001","journal-title":"Anticancer Res."},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960004"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-4622(99)00070-8"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200503000-00005"},{"key":"e_1_2_8_7_2","doi-asserted-by":"crossref","unstructured":"Aggarwal B.B. A. Kumar M.S. Aggarwal et al.2005.Curcumin derived from turmeric (Curcuma longa): a spice for all seasons. In Phytochemicals in Cancer Chemoprevention. P.D. Debasis Bagchi & H.G. Preuss Eds.:349\u2010387. CRC Press. New York.","DOI":"10.1201\/9780203506707.ch23"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03767.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0354OC"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404751200"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705241"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093941"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3863"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00474.2002"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1320"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204997"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206048"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.64.503"},{"key":"e_1_2_8_19_2","first-page":"74","article-title":"Effect of curcumin analogues on oxidation of haemoglobin and lysis of erythrocytes","volume":"84","author":"Venkatesan P.","year":"2003","journal-title":"Curr. Sci."},{"key":"e_1_2_8_20_2","first-page":"574","article-title":"Anti\u2010inflammatory activity of curcumin analogues","volume":"77","author":"Rao T.S.","year":"1982","journal-title":"Indian J. Med. Res."},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1476-5586(03)80057-X"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00170-2"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2516(97)86899-9"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1993.tb07109.x"},{"key":"e_1_2_8_25_2","first-page":"219","article-title":"Anti\u2010tumour studies of metal chelates of synthetic curcuminoids","volume":"21","author":"John V.D.","year":"2002","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00116-5"},{"key":"e_1_2_8_27_2","first-page":"274","article-title":"Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress","volume":"7","author":"Rukkumani R.","year":"2004","journal-title":"J. Pharm. Pharm. Sci."},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nass\/2.1.277"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.02.039"},{"key":"e_1_2_8_30_2","first-page":"120","article-title":"Synthetic derivatives of curcumin and their activity against Leishmania amazonensis","volume":"52","author":"Gomes Dde C.","year":"2002","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.5.911"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(92)90230-Y"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760310001643339"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1211\/0022357001774886"},{"key":"e_1_2_8_35_2","first-page":"169","article-title":"Free radical scavenging activity of curcuminoids","volume":"46","author":"Sreejayan N.","year":"1996","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(99)00096-4"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60.108"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00092-5"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00832-6"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208446"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00781-9"},{"key":"e_1_2_8_42_2","first-page":"3699","article-title":"Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori","volume":"23","author":"Mahady G.B.","year":"2003","journal-title":"Anticancer Res."},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/np970555g"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh165"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(03)00381-1"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf001129v"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203614"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.v21.i2.60"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0262-1746(86)90146-0"},{"key":"e_1_2_8_50_2","first-page":"563","article-title":"Cytotoxicity, ROS\u2010generation activity and radical\u2010scavenging activity of curcumin and related compounds","volume":"24","author":"Fujisawa S.","year":"2004","journal-title":"Anticancer Res."},{"key":"e_1_2_8_51_2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0090-9556(24)15211-7","article-title":"Biotransformation of curcumin through reduction and glucuronidation in mice","volume":"27","author":"Pan M.H.","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"e_1_2_8_52_2","first-page":"3481","article-title":"Antitumor agents","volume":"10","author":"Ishida J.","year":"2002","journal-title":"Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents. Bioorg. Med. Chem."},{"key":"e_1_2_8_53_2","first-page":"327","article-title":"Protection of pancreatic beta\u2010cell by the potential antioxidant bis\u2010o\u2010hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes","volume":"6","author":"Srivivasan A.","year":"2003","journal-title":"J. Pharm. Pharm. Sci."},{"key":"e_1_2_8_54_2","first-page":"5037","article-title":"Antitumor agents","volume":"45","author":"Ohtsu H.","year":"2002","journal-title":"217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. J. Med. Chem."}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1196%2Fannals.1352.010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1196\/annals.1352.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T21:14:31Z","timestamp":1736198071000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1196\/annals.1352.010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1196\/annals.1352.010"],"URL":"https:\/\/doi.org\/10.1196\/annals.1352.010","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}