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Its activation is induced by a wide variety of agents including stress, cigarette smoke, viruses, bacteria, inflammatory stimuli, cytokines, free radicals, carcinogens, tumor promoters, and endotoxins. On activation, NF\u2010\u03baB regulates the expression of almost 400 different genes, which include enzymes (e.g., COX\u20102, 5\u2010LOX, and iNOS), cytokines (such as TNF, IL\u20101, IL\u20106, IL\u20108, and chemokines), adhesion molecules, cell cycle regulatory molecules, viral proteins, and angiogenic factors. The constitutive activation of NF\u2010\u03baB has been linked with a wide variety of human diseases, including asthma, atherosclerosis, AIDS, rheumatoid arthritis, diabetes, osteoporosis, Alzheimer's disease, and cancer. Several agents are known to suppress NF\u2010\u03baB activation, including Th2 cytokines (IL\u20104, IL\u201013, and IL\u201010), interferons, endocrine hormones (LH, HCG, MSH, and GH), phytochemicals, corticosteroids, and immunosuppressive agents. Because of the strong link of NF\u2010\u03baB with different stress signals, it has been called a \u201csmoke\u2010sensor\u201d of the body.<\/jats:p>","DOI":"10.1196\/annals.1352.026","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T21:37:40Z","timestamp":1135978660000},"page":"218-233","source":"Crossref","is-referenced-by-count":378,"title":["Transcription Factor NF\u2010\u03baB: A Sensor for Smoke and Stress Signals"],"prefix":"10.1111","volume":"1056","author":[{"given":"KWANG SEOK","family":"AHN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BHARAT B.","family":"AGGARWAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.003"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1184"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400963200"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1066"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403449200"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/43466"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/89769"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213115200"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13245"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202811"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.18.13297"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212389200"},{"key":"e_1_2_7_14_2","first-page":"8549","article-title":"Pervanadate\u2010induced nuclear factor\u2010kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha","volume":"275","author":"Mukhopadhyay A.","year":"2000","journal-title":"Comparison with tumor necrosis factor-alpha. 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